Pseudomonas aeruginosa LESB58, PALES_19001 (gyrA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_19001
|
| Name |
gyrA
|
| Replicon | chromosome |
| Genomic location | 2043631 - 2046402 (+ strand) |
Cross-References
| RefSeq | YP_002439504 |
| GI | 218890640 |
| Entrez | 7176539 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
DNA gyrase subunit A
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -40.06 |
| Kyte-Doolittle Hydrophobicity Value | -0.243 |
| Molecular Weight (kDa) | 101.1 |
| Isoelectric Point (pI) | 4.62 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones | Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. [PMID:22821356, PMID:8540700] | ARO:3003684 | protein variant model | T83I | Strict | 1749.9 | 99.89 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 631 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG002447 (536 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_19001
Search term: gyrA
Search term: DNA gyrase subunit A
|
Human Homologs
References
No references are associated with this feature.