Pseudomonas aeruginosa 2192, PA2G_02777

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa 2192
GCF_000152545.1|latest
Locus Tag
PA2G_02777
Name
Replicon chromosome
Genomic location 3108982 - 3110139 (- strand)

Cross-References

RefSeq ZP_04935373.1
GI 254242051
NCBI Locus Tag PA2G_02777
UniProtKB Acc A3LDG1
UniProtKB ID A3LDG1_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
aliphatic amidase expression-regulating protein
Synonyms
Evidence for Translation
Charge (pH 7) -6.74
Kyte-Doolittle Hydrophobicity Value -0.320
Molecular Weight (kDa) 42.8
Isoelectric Point (pI) 5.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1QNL TRANSFERASE 10/19/99 AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH BUTYRAMIDE PSEUDOMONAS AERUGINOSA 2.7 X-RAY DIFFRACTION 98.2
1QO0 BINDING PROTEIN 10/26/99 Amide receptor of the amidase operon of Pseudomonas aeruginosa (AmiC) complexed with the negative regulator AmiR. PSEUDOMONAS AERUGINOSA 2.25 X-RAY DIFFRACTION 98.4
1PEA BINDING PROTEIN 11/16/95 AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 98.4

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Butyramide DB02121 DrugBank 5.1.4 P27017 Aliphatic amidase expression-regulating protein 99.7 385 2.1e-226
Acetamide DB02736 DrugBank 5.1.4 P27017 Aliphatic amidase expression-regulating protein 99.7 385 2.1e-226

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002264 (348 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2G_02777

Human Homologs

References

No references are associated with this feature.