Pseudomonas aeruginosa LESB58, PALES_37401 (lpdG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest
Locus Tag
PALES_37401
Name
lpdG
Replicon chromosome
Genomic location 4138333 - 4139769 (- strand)

Cross-References

RefSeq YP_002441323
GI 218892456
Entrez 7181056

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydrolipoamide dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -0.22
Kyte-Doolittle Hydrophobicity Value 0.135
Molecular Weight (kDa) 50.2
Isoelectric Point (pI) 6.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5U8U OXIDOREDUCTASE 12/15/16 Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain UCBPP-PA14) 1.35 X-RAY DIFFRACTION 100.0
5U8W OXIDOREDUCTASE 12/15/16 Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa bound to NADH Pseudomonas aeruginosa (strain UCBPP-PA14) 1.79 X-RAY DIFFRACTION 100.0
5U8V OXIDOREDUCTASE 12/15/16 Dihydrolipoamide dehydrogenase (LpdG) from Pseudomonas aeruginosa bound to NAD+ Pseudomonas aeruginosa (strain UCBPP-PA14) 1.45 X-RAY DIFFRACTION 100.0
1LPF OXIDOREDUCTASE 10/26/92 THREE-DIMENSIONAL STRUCTURE OF LIPOAMIDE DEHYDROGENASE FROM PSEUDOMONAS FLUORESCENS AT 2.8 ANGSTROMS RESOLUTION. ANALYSIS OF REDOX AND THERMOSTABILITY PROPERTIES Pseudomonas fluorescens 2.8 X-RAY DIFFRACTION 99.8

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Flavin adenine dinucleotide DB03147 DrugBank 5.1.4 P14218 Dihydrolipoyl dehydrogenase 99.8 478 1.6e-265

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 650 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003776 (538 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PALES_37401
Search term: lpdG

Human Homologs

Ensembl 110, assembly GRCh38.p14
dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898]
E-value: 1.1e-120
Percent Identity: 49.8
Ensembl 110, assembly GRCh38.p14
dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898]
E-value: 1.1e-120
Percent Identity: 49.8

References

No references are associated with this feature.