Pseudomonas aeruginosa LESB58, PALES_40631 (aprA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_40631
|
| Name |
aprA
|
| Replicon | chromosome |
| Genomic location | 4483931 - 4485370 (- strand) |
Cross-References
| RefSeq | YP_002441646 |
| GI | 218892777 |
| Entrez | 7179607 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
alkaline metalloproteinase precursor
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -28.31 |
| Kyte-Doolittle Hydrophobicity Value | -0.217 |
| Molecular Weight (kDa) | 50.4 |
| Isoelectric Point (pI) | 4.09 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 3VI1 | HYDROLASE | 09/13/11 | Crystal structure of Pseudomonas aerginosa alkaline protease complexed with Substance P(1-6) | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 2 | X-RAY DIFFRACTION | 99.8 |
| 1AKL | HYDROLASE (METALLOPROTEINASE) | 09/16/95 | ALKALINE PROTEASE FROM PSEUDOMONAS AERUGINOSA IFO3080 | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 99.8 |
| 1JIW | HYDROLASE/HYDROLASE INHIBITOR | 07/03/01 | Crystal structure of the APR-APRin complex | Pseudomonas aeruginosa | 1.74 | X-RAY DIFFRACTION | 99.8 |
| 1KAP | ZINC METALLOPROTEASE | 06/08/95 | THREE-DIMENSIONAL STRUCTURE OF THE ALKALINE PROTEASE OF PSEUDOMONAS AERUGINOSA: A TWO-DOMAIN PROTEIN WITH A CALCIUM BINDING PARALLEL BETA ROLL MOTIF | Pseudomonas aeruginosa | 1.64 | X-RAY DIFFRACTION | 99.8 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 128 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001201 (1272 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_40631
Search term: aprA
Search term: alkaline metalloproteinase precursor
|
Human Homologs
References
No references are associated with this feature.