Pseudomonas aeruginosa PAO1, PA2966 (acpP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2966
Name
acpP
Replicon chromosome
Genomic location 3324947 - 3325183 (- strand)

Cross-References

RefSeq NP_251656.1
GI 15598162
Affymetrix PA2966_acpP_at
Entrez 879895
GenBank AAG06354.1
INSDC AAG06354.1
NCBI Locus Tag PA2966
protein_id(GenBank) gb|AAG06354.1|AE004722_10|gnl|PseudoCAP|PA2966
TIGR NTL03PA02966
UniParc UPI0000165EC8
UniProtKB Acc O54439
UniProtKB ID ACP1_PSEAE
UniRef100 UniRef100_O54439
UniRef50 UniRef50_P94123
UniRef90 UniRef90_O54439

Product

Feature Type CDS
Coding Frame 1
Product Name
acyl carrier protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -14.76
Kyte-Doolittle Hydrophobicity Value -0.301
Molecular Weight (kDa) 8.7
Isoelectric Point (pI) 3.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 578 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002616 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2966
Search term: acpP

Human Homologs

Ensembl 110, assembly GRCh38.p14
NADH:ubiquinone oxidoreductase subunit AB1 [Source:HGNC Symbol;Acc:HGNC:7694]
E-value: 3.4e-08
Percent Identity: 44.3
Ensembl 110, assembly GRCh38.p14
NADH:ubiquinone oxidoreductase subunit AB1 [Source:HGNC Symbol;Acc:HGNC:7694]
E-value: 3.4e-08
Percent Identity: 44.3

References

Three-dimensional structure of acyl carrier protein in solution determined by nuclear magnetic resonance and the combined use of dynamical simulated annealing and distance geometry.
Holak TA, Nilges M, Prestegard JH, Gronenborn AM, Clore GM
Eur J Biochem 1988 Jul 15;175(1):9-15
PubMed ID: 3402450
The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes.
Rawlings M, Cronan JE Jr
J Biol Chem 1992 Mar 25;267(9):5751-4
PubMed ID: 1556094
The cloning and overexpression of E. coli acyl carrier protein (ACP).
Jones AL, Kille P, Dancer JE, Harwood JL
Biochem Soc Trans 1993 May;21(2):202S
PubMed ID: 8359454
Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD).
Kutchma AJ, Hoang TT, Schweizer HP
J Bacteriol 1999 Sep;181(17):5498-504
PubMed ID: 10464226
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142