Pseudomonas aeruginosa PAO1, PA3686 (adk)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA3686
Name
adk
Replicon chromosome
Genomic location 4126948 - 4127595 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_252376.1
GI 15598882
Affymetrix PA3686_adk_at
DNASU PaCD00007615
Entrez 879082
GenBank AAG07074.1
INSDC AAG07074.1
NCBI Locus Tag PA3686
protein_id(GenBank) gb|AAG07074.1|AE004788_4|gnl|PseudoCAP|PA3686
TIGR NTL03PA03686
UniParc UPI000012DBDF
UniProtKB Acc Q9HXV4
UniProtKB ID KAD_PSEAE
UniRef100 UniRef100_B7V109
UniRef50 UniRef50_Q7N0P5
UniRef90 UniRef90_A6V1A1

Product

Feature Type CDS
Coding Frame 1
Product Name
adenylate kinase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Charge (pH 7) -2.35
Kyte-Doolittle Hydrophobicity Value -0.200
Molecular Weight (kDa) 23.1
Isoelectric Point (pI) 6.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 631 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001991 (552 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3686
Search term: adk
Search term: adenylate kinase

Human Homologs

Ensembl 97, assembly GRCh38.p12
adenylate kinase 2 [Source:HGNC Symbol;Acc:HGNC:362]
E-value: 1.1e-49
Percent Identity: 50.0
Ensembl 97, assembly GRCh38.p12
adenylate kinase 2 [Source:HGNC Symbol;Acc:HGNC:362]
E-value: 1.1e-49
Percent Identity: 50.0
Ensembl 97, assembly GRCh38.p12
adenylate kinase 2 [Source:HGNC Symbol;Acc:HGNC:362]
E-value: 1.1e-49
Percent Identity: 50.0

References

Electrophoretic variation in adenylate kinase of Neisseria meningitidis is due to inter- and intraspecies recombination.
Feil E, Carpenter G, Spratt BG
Proc. Natl. Acad. Sci. U.S.A. 1995 Nov;92(23):10535-9
PubMed ID: 7479835
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011 ;2
PubMed ID: 21863142