Pseudomonas aeruginosa PAO1, PA5240 (trxA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5240
Name
trxA
Replicon chromosome
Genomic location 5900369 - 5900695 (- strand)

Cross-References

RefSeq NP_253927.1
GI 15600433
Affymetrix PA5240_trxA_at
DNASU PaCD00008257
Entrez 877946
GenBank AAG08625.1
INSDC AAG08625.1
NCBI Locus Tag PA5240
protein_id(GenBank) gb|AAG08625.1|AE004936_8|gnl|PseudoCAP|PA5240
TIGR NTL03PA05241
UniParc UPI0000136E95
UniProtKB Acc Q9X2T1
UniProtKB ID THIO_PSEAE
UniRef100 UniRef100_Q9X2T1
UniRef50 UniRef50_P07887
UniRef90 UniRef90_Q9X2T1

Product

Feature Type CDS
Coding Frame 1
Product Name
thioredoxin
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Charge (pH 7) -4.86
Kyte-Doolittle Hydrophobicity Value -0.117
Molecular Weight (kDa) 11.9
Isoelectric Point (pI) 4.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 640 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004820 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5240
Search term: trxA
Search term: thioredoxin

Human Homologs

Ensembl 110, assembly GRCh38.p14
thioredoxin 2 [Source:HGNC Symbol;Acc:HGNC:17772]
E-value: 1.6e-16
Percent Identity: 37.4
Ensembl 110, assembly GRCh38.p14
thioredoxin 2 [Source:HGNC Symbol;Acc:HGNC:17772]
E-value: 1.6e-16
Percent Identity: 37.4

References

Nucleotide sequence of the thioredoxin gene from Escherichia coli.
Höög JO, von Bahr-Lindström H, Josephson S, Wallace BJ, Kushner SR, Jörnvall H, Holmgren A
Biosci Rep 1984 Nov;4(11):917-23
PubMed ID: 6098320
High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin.
Jeng MF, Campbell AP, Begley T, Holmgren A, Case DA, Wright PE, Dyson HJ
Structure 1994 Sep 15;2(9):853-68
PubMed ID: 7812718
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142