Pseudomonas aeruginosa PAO1, PA0582 (folB)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0051188 | obsolete cofactor biosynthetic process | Inferred from Sequence or Structural Similarity | ECO:0000044 sequence similarity evidence |
||
| Molecular Function | GO:0004150 | dihydroneopterin aldolase activity |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00526
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006760 | folic acid-containing compound metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00526
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| PseudoCyc | PWY-6612 | superpathway of tetrahydrofolate biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | ALL-CHORISMATE-PWY | superpathway of chorismate metabolism | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | PWY-6147 | 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae00790 | Folate biosynthesis | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| SMART | SM00905 | FolB_2 | IPR006157 | Dihydroneopterin aldolase/epimerase domain | 4 | 114 | 1.2E-50 |
| NCBIfam | TIGR00526 | JCVI: FolB domain | IPR006157 | Dihydroneopterin aldolase/epimerase domain | 1 | 115 | 1.1E-31 |
| Gene3D | G3DSA:3.30.1130.10 | - | IPR043133 | GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase | 1 | 115 | 6.8E-37 |
| PANTHER | PTHR42844 | DIHYDRONEOPTERIN ALDOLASE 1-RELATED | IPR006156 | Dihydroneopterin aldolase | 2 | 114 | 1.0E-21 |
| Pfam | PF02152 | Dihydroneopterin aldolase | IPR006157 | Dihydroneopterin aldolase/epimerase domain | 4 | 113 | 7.0E-32 |
| FunFam | G3DSA:3.30.1130.10:FF:000002 | 7,8-dihydroneopterin aldolase | - | - | 1 | 117 | 2.7E-47 |
| CDD | cd00534 | DHNA_DHNTPE | IPR006157 | Dihydroneopterin aldolase/epimerase domain | 1 | 115 | 3.76587E-29 |
| SUPERFAMILY | SSF55620 | Tetrahydrobiopterin biosynthesis enzymes-like | - | - | 1 | 115 | 5.39E-36 |
| NCBIfam | TIGR00525 | JCVI: dihydroneopterin aldolase | IPR006156 | Dihydroneopterin aldolase | 2 | 114 | 2.0E-24 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.