Pseudomonas aeruginosa PAO1, PA0782 (putA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 6819140 Reviewed by curator
Molecular Function GO:0004657 proline dehydrogenase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 6819140 Reviewed by curator
Biological Process GO:0010133 proline catabolic process to glutamate
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 6819140 Reviewed by curator
Biological Process GO:0010133 proline catabolic process to glutamate
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004657 proline dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01238
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003700 DNA-binding transcription factor activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.309.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006355 regulation of transcription, DNA-templated
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006561 proline biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01238
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF53720
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00330 Arginine and proline metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Arginine and proline metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00250 Alanine, aspartate and glutamate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glutamate metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.20.20.220 - - - 144 532 1.3E-120
Gene3D G3DSA:3.40.605.10 Aldehyde Dehydrogenase; Chain A, domain 1 IPR016162 Aldehyde dehydrogenase, N-terminal 565 1039 0.0
Gene3D G3DSA:3.40.309.10 Aldehyde Dehydrogenase; Chain A, domain 2 IPR016163 Aldehyde dehydrogenase, C-terminal 816 1007 0.0
SUPERFAMILY SSF53720 ALDH-like IPR016161 Aldehyde/histidinol dehydrogenase 553 1042 1.23E-127
FunFam G3DSA:3.20.20.220:FF:000004 Bifunctional protein PutA - - 146 532 0.0
Pfam PF00171 Aldehyde dehydrogenase family IPR015590 Aldehyde dehydrogenase domain 583 1037 3.1E-113
SUPERFAMILY SSF51730 FAD-linked oxidoreductase IPR029041 FAD-linked oxidoreductase-like 190 540 4.32E-114
NCBIfam TIGR01238 JCVI: L-glutamate gamma-semialdehyde dehydrogenase IPR005933 Bifunctional protein PutA, C-terminal domain 533 1037 0.0
Gene3D G3DSA:1.20.5.460 Single helix bin - - 88 113 2.5E-13
PANTHER PTHR42862 DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED - - 165 1055 0.0
FunFam G3DSA:3.40.309.10:FF:000005 1-pyrroline-5-carboxylate dehydrogenase 1 - - 816 1007 8.8E-57
SUPERFAMILY SSF81935 N-terminal domain of bifunctional PutA protein IPR024089 Proline dehydrogenase PutA, domain I/II 19 189 1.83E-62
CDD cd07125 ALDH_PutA-P5CDH - - 490 1054 0.0
PIRSF PIRSF000197 Bifunct_PutA IPR025703 Bifunctional protein PutA 4 1057 0.0
Pfam PF14850 DNA-binding domain of Proline dehydrogenase IPR024082 Proline dehydrogenase PutA, domain II 74 187 1.5E-45
Pfam PF01619 Proline dehydrogenase IPR002872 Proline dehydrogenase domain 197 496 1.2E-90

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.