Pseudomonas aeruginosa PAO1, PA1546 (hemN)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0004109 | coproporphyrinogen oxidase activity | Inferred from Genetic Interaction | ECO:0000316 genetic interaction evidence used in manual assertion |
9767567 | Reviewed by curator |
| Biological Process | GO:0051188 | obsolete cofactor biosynthetic process | Inferred from Direct Assay | ECO:0000002 direct assay evidence |
||
| Cellular Component | GO:0005737 | cytoplasm |
Inferred from Sequence Model
Term mapped from: InterPro:SFLDF00277
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003824 | catalytic activity |
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0004109 | coproporphyrinogen oxidase activity |
Inferred from Sequence Model
Term mapped from: InterPro:SFLDF00277
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006779 | porphyrin-containing compound biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:SFLDF00277
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| PseudoCyc | HEMESYN2-PWY | heme biosynthesis II (anaerobic) | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Gene3D | G3DSA:3.80.30.20 | tm_1862 like domain | IPR023404 | Radical SAM, alpha/beta horseshoe | 61 | 284 | 2.4E-14 |
| Gene3D | G3DSA:1.10.10.920 | - | - | - | 368 | 460 | 1.9E-31 |
| CDD | cd01335 | Radical_SAM | - | - | 63 | 255 | 3.27079E-8 |
| SUPERFAMILY | SSF102114 | Radical SAM enzymes | - | - | 5 | 448 | 0.0 |
| PIRSF | PIRSF000167 | HemN | IPR004558 | Oxygen-independent coproporphyrinogen III oxidase HemN | 3 | 459 | 0.0 |
| SFLD | SFLDF00277 | oxygen-independent coproporphyrinogen-III oxidase 1 (HemN-like) | IPR004558 | Oxygen-independent coproporphyrinogen III oxidase HemN | 3 | 460 | 0.0 |
| FunFam | G3DSA:1.10.10.920:FF:000002 | Coproporphyrinogen-III oxidase | - | - | 368 | 460 | 1.4E-47 |
| SFLD | SFLDG01065 | anaerobic coproporphyrinogen-III oxidase like | - | - | 3 | 460 | 0.0 |
| Pfam | PF06969 | HemN C-terminal domain | IPR010723 | HemN, C-terminal | 369 | 435 | 5.7E-10 |
| Pfam | PF04055 | Radical SAM superfamily | IPR007197 | Radical SAM | 58 | 232 | 5.4E-18 |
| SFLD | SFLDG01082 | B12-binding domain containing | - | - | 63 | 254 | 8.6E-17 |
| SMART | SM00729 | MiaB | IPR006638 | Elp3/MiaA/NifB-like, radical SAM core domain | 53 | 276 | 4.8E-51 |
| PANTHER | PTHR13932 | COPROPORPHYRINIGEN III OXIDASE | IPR034505 | Anaerobic coproporphyrinogen-III oxidase | 14 | 448 | 2.3E-94 |
| NCBIfam | TIGR00538 | JCVI: oxygen-independent coproporphyrinogen III oxidase | IPR004558 | Oxygen-independent coproporphyrinogen III oxidase HemN | 6 | 460 | 0.0 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.