Pseudomonas aeruginosa PAO1, PA1636 (kdpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8276778 Reviewed by curator
Biological Process GO:0007234 osmosensory signaling via phosphorelay pathway
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8276778 Reviewed by curator
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0000160 phosphorelay signal transduction system
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00082
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004673 protein histidine kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Two-component regulatory systems Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Two-component System ECO:0000037
not_recorded
KEGG pae02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.50.300 - IPR027417 P-loop containing nucleoside triphosphate hydrolase 16 226 3.2E-98
SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like - - 248 358 1.05E-13
FunFam G3DSA:3.30.565.10:FF:000042 Two-component sensor histidine kinase KdpD - - 722 876 6.3E-46
PANTHER PTHR45569 SENSOR PROTEIN KDPD - - 2 876 0.0
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 833 851 8.1E-14
SMART SM00388 HisKA_10 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 650 718 1.2E-17
CDD cd01987 USP_OKCHK - - 248 365 1.62601E-32
Pfam PF00582 Universal stress protein family IPR006016 UspA 248 358 2.6E-11
CDD cd00082 HisKA IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 648 714 7.21477E-15
CDD cd00075 HATPase - - 767 870 6.47675E-33
Gene3D G3DSA:1.20.120.620 Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd, IPR038318 KdpD, transmembrane domain superfamily 385 489 2.0E-27
FunFam G3DSA:1.10.287.130:FF:000027 Sensor histidine kinase KdpD - - 645 717 1.7E-42
Pfam PF00512 His Kinase A (phospho-acceptor) domain IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 651 718 5.6E-14
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 799 813 8.1E-14
Gene3D G3DSA:3.40.50.620 HUPs IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 229 361 1.3E-14
SUPERFAMILY SSF47384 Homodimeric domain of signal transducing histidine kinase IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily 646 719 1.9E-16
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 767 873 2.0E-22
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 708 876 1.57E-37
FunFam G3DSA:3.40.50.300:FF:000483 Sensor histidine kinase KdpD - - 16 226 2.3E-99
Pfam PF02702 Osmosensitive K+ channel His kinase sensor domain IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal 19 227 9.7E-91
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 762 874 1.5E-32
Coils Coil Coil - - 692 712 -
Gene3D G3DSA:1.10.287.130 - - - 645 717 8.8E-18
Pfam PF13493 Domain of unknown function (DUF4118) IPR025201 Sensor protein KdpD, transmembrane domain 390 494 2.5E-26
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 817 827 8.1E-14
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 733 878 5.2E-35
Gene3D G3DSA:3.30.450.40 - IPR029016 GAF-like domain superfamily 501 644 1.2E-23
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 858 871 8.1E-14
SUPERFAMILY SSF55781 GAF domain-like - - 495 637 3.05E-5

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.