Pseudomonas aeruginosa PAO1, PA1770 (ppsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006091 generation of precursor metabolites and energy
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006094 gluconeogenesis
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P23538
 ECO:0000250
sequence similarity evidence used in manual assertion		 4383555 Reviewed by curator
Molecular Function GO:0004743 pyruvate kinase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 1310524 Reviewed by curator
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02896
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008986 pyruvate, water dikinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000854
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.30.1490.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02896
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016301 kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01326
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF51621
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006090 pyruvate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000854
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class
Energy metabolism Other PAO1 genes in this class
Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc GLYCOLYSIS-E-D superpathway of glycolysis and Entner-Doudoroff 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc P22-PWY acetyl-CoA assimilation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Reductive carboxylate cycle (CO2 fixation) ECO:0000037
not_recorded
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc P461-PWY hexitol fermentation to lactate, formate, ethanol and acetate 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc GLYCOLYSIS+CITRIC-ACID-PWY glycolysis + citric acid pathway 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00680 Methane metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc GLUCONEO-PWY gluconeogenesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-5484 glycolysis II (from fructose 6-phosphate) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc GLYCOLYSIS glycolysis I (from glucose 6-phosphate) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc P81-PWY glyceraldehyde 3-phosphate degradation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.20.20.60 - IPR040442 Pyruvate kinase-like domain superfamily 477 787 1.6E-102
FunFam G3DSA:3.30.470.20:FF:000017 Phosphoenolpyruvate synthase - - 193 356 7.2E-87
Gene3D G3DSA:3.30.1490.20 - IPR013815 ATP-grasp fold, subdomain 1 2 192 9.2E-67
Gene3D G3DSA:3.30.470.20 - - - 193 356 7.3E-57
FunFam G3DSA:3.20.20.60:FF:000010 Phosphoenolpyruvate synthase - - 477 788 0.0
Pfam PF02896 PEP-utilising enzyme, PEP-binding domain IPR000121 PEP-utilising enzyme, C-terminal 481 780 1.3E-62
FunFam G3DSA:3.50.30.10:FF:000002 Phosphoenolpyruvate synthase - - 358 476 1.6E-67
PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature - - 693 708 7.8E-6
PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature - - 710 725 7.8E-6
PIRSF PIRSF000854 PEP_synthase IPR006319 Phosphoenolpyruvate synthase 1 791 0.0
SUPERFAMILY SSF52009 Phosphohistidine domain IPR036637 Phosphohistidine domain superfamily 347 464 5.36E-34
Pfam PF01326 Pyruvate phosphate dikinase, AMP/ATP-binding domain IPR002192 Pyruvate phosphate dikinase, AMP/ATP-binding 17 342 1.9E-119
SUPERFAMILY SSF51621 Phosphoenolpyruvate/pyruvate domain IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily 461 786 1.05E-99
FunFam G3DSA:3.30.1490.20:FF:000010 Phosphoenolpyruvate synthase - - 1 192 7.4E-97
PANTHER PTHR43030 PHOSPHOENOLPYRUVATE SYNTHASE IPR006319 Phosphoenolpyruvate synthase 3 788 0.0
PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature - - 746 758 7.8E-6
NCBIfam TIGR01418 JCVI: pyruvate, water dikinase IPR006319 Phosphoenolpyruvate synthase 5 786 0.0
Pfam PF00391 PEP-utilising enzyme, mobile domain IPR008279 PEP-utilising enzyme, mobile domain 383 454 3.7E-26
Gene3D G3DSA:3.50.30.10 Phosphohistidine domain - - 358 476 2.0E-35
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 1 384 9.3E-109

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.