Pseudomonas aeruginosa PAO1, PA2623 (icd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2682654 Reviewed by curator
Biological Process GO:0044248 cellular catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2682654 Reviewed by curator
Biological Process GO:0015976 carbon utilization
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2682654 Reviewed by curator
Molecular Function GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2682654 Reviewed by curator
Biological Process GO:0006091 generation of precursor metabolites and energy
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2682654 Reviewed by curator
Molecular Function GO:0004450 isocitrate dehydrogenase (NADP+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43504
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006099 tricarboxylic acid cycle
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43504
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Citrate cycle (TCA cycle) ECO:0000037
not_recorded
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc ANARESP1-PWY anaerobic respiration 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glutathione metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00020 Citrate cycle (TCA cycle) 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc TCA TCA cycle I (prokaryotic) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Reductive carboxylate cycle (CO2 fixation) ECO:0000037
not_recorded
PseudoCyc FERMENTATION-PWY mixed acid fermentation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00480 Glutathione metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.40.718.10:FF:000005 Isocitrate dehydrogenase [NADP] - - 2 418 0.0
SMART SM01329 Iso_dh_2 IPR024084 Isopropylmalate dehydrogenase-like domain 30 414 0.0
Gene3D G3DSA:3.40.718.10 Isopropylmalate Dehydrogenase - - 1 418 0.0
PANTHER PTHR43504 ISOCITRATE DEHYDROGENASE [NADP] IPR004439 Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic 3 418 0.0
SUPERFAMILY SSF53659 Isocitrate/Isopropylmalate dehydrogenase-like - - 4 418 0.0
NCBIfam TIGR00183 JCVI: isocitrate dehydrogenase (NADP(+)) IPR004439 Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic 3 418 0.0
Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase IPR024084 Isopropylmalate dehydrogenase-like domain 31 413 1.1E-99

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.