Pseudomonas aeruginosa PAO1, PA2709 (cysK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2709
Name
cysK
Replicon chromosome
Genomic location 3062939 - 3063913 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_251399.1
GI 15597905
Affymetrix PA2709_cysK_at
DNASU PaCD00007169
Entrez 882613
GenBank AAG06097.1
INSDC AAG06097.1
NCBI Locus Tag PA2709
protein_id(GenBank) gb|AAG06097.1|AE004699_2|gnl|PseudoCAP|PA2709
TIGR NTL03PA02709
UniParc UPI00000C57C1
UniProtKB Acc Q9I0D3
UniProtKB ID Q9I0D3_PSEAE
UniRef100 UniRef100_W0YV83
UniRef50 UniRef50_W0YV83
UniRef90 UniRef90_W0YV83

Product

Feature Type CDS
Coding Frame 1
Product Name
cysteine synthase A
Product Name Confidence: Class 2
Synonyms O-acetylserine sulfhydrolase A
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.57
Kyte-Doolittle Hydrophobicity Value -0.037
Molecular Weight (kDa) 34.3
Isoelectric Point (pI) 6.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002857 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2709
Search term: cysK

Human Homologs

Ensembl 110, assembly GRCh38.p14
cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.3e-55
Percent Identity: 40.1
Ensembl 110, assembly GRCh38.p14
cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.3e-55
Percent Identity: 40.1
Ensembl 110, assembly GRCh38.p14
cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.3e-55
Percent Identity: 40.1
Ensembl 110, assembly GRCh38.p14
cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.3e-55
Percent Identity: 40.1

References

Phylogeny of metabolic pathways: O-acetylserine sulphydrylase A is homologous to the tryptophan synthase beta subunit.
Levy S, Danchin A
Mol Microbiol 1988 Nov;2(6):777-83
PubMed ID: 3062311
Analysis of global responses by protein and peptide fingerprinting of proteins isolated by two-dimensional gel electrophoresis. Application to the sulfate-starvation response of Escherichia coli.
Quadroni M, Staudenmann W, Kertesz M, James P
Eur J Biochem 1996 Aug 1;239(3):773-81
PubMed ID: 8774726