Pseudomonas aeruginosa PAO1, PA2876 (pyrF)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0009117 | nucleotide metabolic process | Inferred from Direct Assay | ECO:0000002 direct assay evidence |
||
| Biological Process | GO:0006221 | pyrimidine nucleotide biosynthetic process | Inferred from Sequence or Structural Similarity | ECO:0000250 sequence similarity evidence used in manual assertion |
2956254 | Reviewed by curator |
| Molecular Function | GO:0004590 | orotidine-5'-phosphate decarboxylase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PTHR32119
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0044205 | 'de novo' UMP biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:PTHR32119
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:SM00934
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| PseudoCyc | PWY0-162 | superpathway of pyrimidine ribonucleotides de novo biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | PRPP-PWY | superpathway of histidine, purine, and pyrimidine biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae00240 | Pyrimidine metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCAP | Pyrimidine metabolism |
ECO:0000037
not_recorded |
|||
| PseudoCyc | PWY-5686 | UMP biosynthesis | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Hamap | MF_01200_B | Orotidine 5'-phosphate decarboxylase [pyrF]. | IPR047596 | Orotidine 5'-phosphate decarboxylase, bacterial | 5 | 232 | 39.575012 |
| SMART | SM00934 | OMPdecase_2 | IPR001754 | Orotidine 5'-phosphate decarboxylase domain | 7 | 227 | 1.3E-99 |
| CDD | cd04725 | OMP_decarboxylase_like | - | - | 8 | 216 | 8.59698E-79 |
| SUPERFAMILY | SSF51366 | Ribulose-phoshate binding barrel | IPR011060 | Ribulose-phosphate binding barrel | 5 | 230 | 2.07E-73 |
| FunFam | G3DSA:3.20.20.70:FF:000015 | Orotidine 5'-phosphate decarboxylase | - | - | 2 | 232 | 1.3E-104 |
| NCBIfam | TIGR01740 | JCVI: orotidine-5'-phosphate decarboxylase | IPR014732 | Orotidine 5'-phosphate decarboxylase | 9 | 227 | 7.1E-56 |
| Pfam | PF00215 | Orotidine 5'-phosphate decarboxylase / HUMPS family | IPR001754 | Orotidine 5'-phosphate decarboxylase domain | 6 | 226 | 1.5E-50 |
| Gene3D | G3DSA:3.20.20.70 | Aldolase class I | IPR013785 | Aldolase-type TIM barrel | 1 | 232 | 1.6E-85 |
| PANTHER | PTHR32119 | OROTIDINE 5'-PHOSPHATE DECARBOXYLASE | IPR014732 | Orotidine 5'-phosphate decarboxylase | 1 | 230 | 7.3E-72 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.