Pseudomonas aeruginosa PAO1, PA3646 (lpxD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009245 lipid A biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA14_17180
 ECO:0000250
sequence similarity evidence used in manual assertion		 25173672 Reviewed by curator
Molecular Function GO:0016746 transferase activity, transferring acyl groups
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8293817 Reviewed by curator
Cellular Component GO:0009276 Gram-negative-bacterium-type cell wall
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04613
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016410 N-acyltransferase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43378
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009245 lipid A biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43378
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Lipopolysaccharide biosynthesis ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00540 Lipopolysaccharide biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF04613 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD IPR020573 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, non-repeat region 25 92 8.7E-22
Gene3D G3DSA:1.20.5.170 - - - 313 353 4.4E-20
Hamap MF_00523 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase [lpxD]. IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD 12 329 36.371384
SUPERFAMILY SSF51161 Trimeric LpxA-like enzymes IPR011004 Trimeric LpxA-like superfamily 35 320 2.51E-80
Coils Coil Coil - - 319 346 -
CDD cd03352 LbH_LpxD IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD 112 317 9.22551E-113
PANTHER PTHR43378 UDP-3-O-ACYLGLUCOSAMINE N-ACYLTRANSFERASE IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD 7 340 1.8E-76
Gene3D G3DSA:3.40.1390.10 - - - 2 101 2.2E-37
Gene3D G3DSA:2.160.10.10 Hexapeptide repeat proteins - - 102 312 1.6E-68
NCBIfam TIGR01853 JCVI: UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase IPR007691 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD 11 332 2.3E-117
Pfam PF00132 Bacterial transferase hexapeptide (six repeats) IPR001451 Hexapeptide repeat 149 183 1.5E-6

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.