Pseudomonas aeruginosa PAO1, PA3736 (hom)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009088 threonine biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 10220164 Reviewed by curator
Molecular Function GO:0004412 homoserine dehydrogenase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 10220164 Reviewed by curator
Molecular Function GO:0004412 homoserine dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000098
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03447
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006520 cellular amino acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000098
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03447
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00300 Lysine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc THRESYN-PWY superpathway of L-threonine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc HOMOSERSYN-PWY L-homoserine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc P4-PWY superpathway of L-lysine, L-threonine and L-methionine biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Lysine biosynthesis ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd04881 ACT_HSDH-Hom - - 352 431 5.62111E-30
Pfam PF03447 Homoserine dehydrogenase, NAD binding domain IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding 10 127 3.3E-25
PANTHER PTHR43331 HOMOSERINE DEHYDROGENASE - - 1 321 7.1E-114
SUPERFAMILY SSF55021 ACT-like IPR045865 ACT-like domain 350 420 2.41E-15
PIRSF PIRSF000098 Homoser_dh IPR016204 Homoserine dehydrogenase 1 433 0.0
SUPERFAMILY SSF55347 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain - - 135 300 1.5E-52
Gene3D G3DSA:3.30.360.10 Dihydrodipicolinate Reductase; domain 2 - - 134 346 0.0
Gene3D G3DSA:3.40.50.720 - - - 4 338 0.0
FunFam G3DSA:3.30.360.10:FF:000005 Homoserine dehydrogenase - - 134 302 2.2E-71
Pfam PF01842 ACT domain IPR002912 ACT domain 352 419 3.7E-16
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 1 156 1.16E-35
Pfam PF00742 Homoserine dehydrogenase IPR001342 Homoserine dehydrogenase, catalytic 135 313 7.2E-63
Gene3D G3DSA:3.30.70.260 - - - 347 422 0.0
FunFam G3DSA:3.30.70.260:FF:000030 Homoserine dehydrogenase - - 347 422 1.2E-35

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.