Pseudomonas aeruginosa PAO1, PA3763 (purL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006163 purine nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006189 'de novo' IMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01735
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004642 phosphoribosylformylglycinamidine synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01735
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc superpathway of 5-aminoimidazole ribonucleotide biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc 5-aminoimidazole ribonucleotide biosynthesis I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
PseudoCyc DENOVOPURINE2-PWY superpathway of purine nucleotides de novo biosynthesis II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Purine metabolism ECO:0000037
not_recorded
MetaCyc 5-aminoimidazole ribonucleotide biosynthesis II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF82697 PurS-like IPR036604 Phosphoribosylformylglycinamidine synthase subunit PurS-like superfamily 1 150 1.99E-47
Pfam PF18076 Formylglycinamide ribonucleotide amidotransferase N-terminal IPR040707 Phosphoribosylformylglycinamidine synthase, N-terminal 35 148 4.2E-40
FunFam G3DSA:3.40.50.880:FF:000008 Phosphoribosylformylglycinamidine synthase - - 984 1298 0.0
SMART SM01211 GATase_5_2 - - 1042 1297 0.0
SUPERFAMILY SSF56042 PurM C-terminal domain-like IPR036676 PurM-like, C-terminal domain superfamily 430 612 8.67E-54
SUPERFAMILY SSF55326 PurM N-terminal domain-like IPR036921 PurM-like, N-terminal domain superfamily 219 426 2.23E-63
CDD cd02203 PurL_repeat1 - - 203 598 3.26128E-127
Gene3D G3DSA:3.30.1330.10 - IPR036921 PurM-like, N-terminal domain superfamily 212 418 5.6E-43
FunFam G3DSA:3.90.650.10:FF:000002 Phosphoribosylformylglycinamidine synthase - - 419 604 7.3E-102
Gene3D G3DSA:1.10.8.750 Phosphoribosylformylglycinamidine synthase, linker domain - - 151 211 1.4E-27
Gene3D G3DSA:3.90.650.10 - IPR036676 PurM-like, C-terminal domain superfamily 807 984 8.7E-31
MobiDBLite mobidb-lite consensus disorder prediction - - 298 328 -
Pfam PF13507 CobB/CobQ-like glutamine amidotransferase domain - - 1042 1297 4.7E-107
Hamap MF_00419 Phosphoribosylformylglycinamidine synthase [purL]. IPR010073 Phosphoribosylformylglycinamidine synthase PurL 1 1298 21.370491
Gene3D G3DSA:3.30.1330.10 - IPR036921 PurM-like, N-terminal domain superfamily 622 805 1.6E-22
CDD cd01740 GATase1_FGAR_AT - - 1045 1294 2.60401E-91
FunFam G3DSA:3.30.1330.10:FF:000005 Phosphoribosylformylglycinamidine synthase - - 617 805 1.0E-97
Gene3D G3DSA:3.90.650.10 - IPR036676 PurM-like, C-terminal domain superfamily 419 604 3.4E-53
Coils Coil Coil - - 995 1015 -
FunFam G3DSA:3.90.650.10:FF:000005 Phosphoribosylformylglycinamidine synthase - - 807 983 3.7E-67
Pfam PF02769 AIR synthase related protein, C-terminal domain IPR010918 PurM-like, C-terminal domain 430 586 4.6E-31
FunFam G3DSA:1.10.8.750:FF:000002 Phosphoribosylformylglycinamidine synthase - - 151 211 4.5E-29
SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like IPR029062 Class I glutamine amidotransferase-like 1039 1297 3.96E-96
Pfam PF02769 AIR synthase related protein, C-terminal domain IPR010918 PurM-like, C-terminal domain 836 966 4.9E-15
NCBIfam TIGR01735 JCVI: phosphoribosylformylglycinamidine synthase IPR010073 Phosphoribosylformylglycinamidine synthase PurL 3 1297 0.0
FunFam G3DSA:3.30.1330.10:FF:000002 Phosphoribosylformylglycinamidine synthase - - 212 418 1.6E-115
SUPERFAMILY SSF56042 PurM C-terminal domain-like IPR036676 PurM-like, C-terminal domain superfamily 823 1036 5.08E-56
PANTHER PTHR10099 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE - - 2 1297 0.0
SUPERFAMILY SSF109736 FGAM synthase PurL, linker domain - - 153 218 1.96E-21
CDD cd02204 PurL_repeat2 - - 677 960 1.21099E-77
SUPERFAMILY SSF55326 PurM N-terminal domain-like IPR036921 PurM-like, N-terminal domain superfamily 622 814 2.62E-67
Pfam PF18072 Formylglycinamide ribonucleotide amidotransferase linker domain IPR041609 Phosphoribosylformylglycinamidine synthase, linker domain 169 218 5.4E-23
Gene3D G3DSA:3.40.50.880 - IPR029062 Class I glutamine amidotransferase-like 985 1298 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.