Pseudomonas aeruginosa PAO1, PA3769 (guaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006177 GMP biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3894345 Reviewed by curator
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00888
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006177 GMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00888
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00888
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006164 purine nucleotide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01997
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glutamate metabolism ECO:0000037
not_recorded
PseudoCAP Purine metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00117 Glutamine amidotransferase class-I IPR017926 Glutamine amidotransferase 12 200 1.8E-35
PRINTS PR00097 Anthranilate synthase component II signature - - 81 92 1.5E-5
Hamap MF_00344 GMP synthase [glutamine-hydrolyzing] [guaA]. IPR022955 GMP synthase 7 525 55.919529
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 10 24 8.8E-5
FunFam G3DSA:3.40.50.620:FF:000001 GMP synthase [glutamine-hydrolyzing] - - 209 410 9.9E-102
Gene3D G3DSA:3.30.300.10 - - - 411 525 3.8E-48
Pfam PF00958 GMP synthase C terminal domain IPR001674 GMP synthase, C-terminal 433 524 2.1E-40
PRINTS PR00097 Anthranilate synthase component II signature - - 177 190 1.5E-5
CDD cd01742 GATase1_GMP_Synthase IPR004739 GMP synthase, glutamine amidotransferase 10 198 6.47461E-95
FunFam G3DSA:3.30.300.10:FF:000002 GMP synthase [glutamine-hydrolyzing] - - 411 525 6.1E-54
NCBIfam TIGR00884 JCVI: glutamine-hydrolyzing GMP synthase, C-terminal domain IPR001674 GMP synthase, C-terminal 212 525 0.0
SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like - - 197 420 9.7E-59
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 81 97 8.8E-5
Gene3D G3DSA:3.40.50.620 HUPs IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 209 410 3.2E-78
PRINTS PR00097 Anthranilate synthase component II signature - - 54 63 1.5E-5
PANTHER PTHR11922 GMP SYNTHASE-RELATED - - 10 525 0.0
PRINTS PR00096 Glutamine amidotransferase superfamily signature - - 177 190 5.1E-7
SUPERFAMILY SSF52317 Class I glutamine amidotransferase-like IPR029062 Class I glutamine amidotransferase-like 8 237 1.08E-53
Pfam PF02540 NAD synthase IPR022310 NAD/GMP synthase 219 291 3.5E-8
PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature - - 51 65 8.8E-5
FunFam G3DSA:3.40.50.880:FF:000001 GMP synthase [glutamine-hydrolyzing] - - 7 206 5.1E-86
Gene3D G3DSA:3.40.50.880 - IPR029062 Class I glutamine amidotransferase-like 9 206 4.9E-51
SUPERFAMILY SSF54810 GMP synthetase C-terminal dimerisation domain - - 405 525 3.4E-49
PRINTS PR00096 Glutamine amidotransferase superfamily signature - - 81 92 5.1E-7
NCBIfam TIGR00888 JCVI: glutamine-hydrolyzing GMP synthase, N-terminal domain IPR004739 GMP synthase, glutamine amidotransferase 10 204 2.5E-76
PRINTS PR00096 Glutamine amidotransferase superfamily signature - - 54 63 5.1E-7
CDD cd01997 GMP_synthase_C IPR001674 GMP synthase, C-terminal 229 524 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.