Pseudomonas aeruginosa PAO1, PA4524 (nadC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8419294 Reviewed by curator
Biological Process GO:0009435 NAD biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01729
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016763 transferase activity, transferring pentosyl groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.90.1170.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01729
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PYRIDNUCSYN-PWY NAD biosynthesis I (from aspartate) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00760 Nicotinate and nicotinamide metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Nicotinate and nicotinamide metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF54675 Nicotinate/Quinolinate PRTase N-terminal domain-like - - 12 114 7.06E-32
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 123 275 9.2E-111
Gene3D G3DSA:3.90.1170.20 - IPR037128 Quinolinate phosphoribosyl transferase, N-terminal domain superfamily 24 278 9.2E-111
Pfam PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain IPR022412 Quinolinate phosphoribosyl transferase, N-terminal 25 113 3.4E-26
FunFam G3DSA:3.20.20.70:FF:000030 Nicotinate-nucleotide pyrophosphorylase, carboxylating - - 129 270 2.4E-60
SUPERFAMILY SSF51690 Nicotinate/Quinolinate PRTase C-terminal domain-like IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal 116 280 1.77E-60
CDD cd01572 QPRTase IPR004393 Nicotinate-nucleotide pyrophosphorylase 15 279 0.0
FunFam G3DSA:3.90.1170.20:FF:000007 Nicotinate-nucleotide pyrophosphorylase (Carboxylating) - - 20 131 8.4E-59
NCBIfam TIGR00078 JCVI: carboxylating nicotinate-nucleotide diphosphorylase IPR004393 Nicotinate-nucleotide pyrophosphorylase 17 279 2.8E-94
PIRSF PIRSF006250 NadC_ModD IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD 7 282 9.6E-110
PANTHER PTHR32179 NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] IPR027277 Nicotinate-nucleotide pyrophosphorylase/Putative pyrophosphorylase ModD 10 280 3.9E-89
Pfam PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain IPR002638 Quinolinate phosphoribosyl transferase, C-terminal 116 279 1.5E-56

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.