Pseudomonas aeruginosa PAO1, PA4771 (lldD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004459 L-lactate dehydrogenase activity
IGI
Inferred from Genetic Interaction
Term mapped from: PseudoCAP:PA2382
 ECO:0000316
genetic interaction evidence used in manual assertion		 30066495 Reviewed by curator
Biological Process GO:0019516 lactate oxidation
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 8407843 Reviewed by curator
Molecular Function GO:0004459 L-lactate dehydrogenase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 18473 Reviewed by curator
Molecular Function GO:0010181 FMN binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01559
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006089 lactate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01559
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000138
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004457 lactate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01559
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc LCTACACAT-PWY lactate oxidation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc P122-PWY heterolactic fermentation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc P461-PWY hexitol fermentation to lactate, formate, ethanol and acetate 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-5481 pyruvate fermentation to lactate 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc P41-PWY pyruvate fermentation to acetate and lactate I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd02809 alpha_hydroxyacid_oxid_FMN IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent 8 371 0.0
PIRSF PIRSF000138 Al-hdrx_acd_dh IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent 2 379 2.2E-122
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 3 379 7.6E-124
SUPERFAMILY SSF51395 FMN-linked oxidoreductases - - 7 374 2.56E-98
Pfam PF01070 FMN-dependent dehydrogenase IPR000262 FMN-dependent dehydrogenase 13 375 1.8E-125
PANTHER PTHR10578 S -2-HYDROXY-ACID OXIDASE-RELATED - - 5 376 7.7E-104
Hamap MF_01559 L-lactate dehydrogenase [lldD]. IPR020920 L-lactate dehydrogenase, bacterial 1 380 75.02739
NCBIfam NF033901 NCBIFAM: FMN-dependent L-lactate dehydrogenase LldD IPR020920 L-lactate dehydrogenase, bacterial 1 377 0.0
FunFam G3DSA:3.20.20.70:FF:000029 L-lactate dehydrogenase - - 2 380 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.