Pseudomonas aeruginosa PAO1, PA4868 (ureC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Cellular Component GO:0035550 urease complex
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 7559354 Reviewed by curator
Biological Process GO:0043419 urea catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 7559354 Reviewed by curator
Molecular Function GO:0009039 urease activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 7559354 Reviewed by curator
Molecular Function GO:0016151 nickel cation binding
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 7559354 Reviewed by curator
Molecular Function GO:0016787 hydrolase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01979
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016151 nickel cation binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01953
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006807 nitrogen compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01953
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF51338
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0009039 urease activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01953
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-5704 urea degradation II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00220 Arginine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Hamap MF_01953 Urease subunit alpha [ureC]. IPR005848 Urease, alpha subunit 1 566 56.785484
Gene3D G3DSA:3.20.20.140 - - - 128 566 0.0
PRINTS PR01752 Urea amidohydrolase (urease) protein signature IPR005848 Urease, alpha subunit 426 439 6.5E-34
PRINTS PR01752 Urea amidohydrolase (urease) protein signature IPR005848 Urease, alpha subunit 333 349 6.5E-34
SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases IPR011059 Metal-dependent hydrolase, composite domain superfamily 2 176 4.07E-63
Pfam PF01979 Amidohydrolase family IPR006680 Amidohydrolase-related 124 450 4.2E-79
SUPERFAMILY SSF51556 Metallo-dependent hydrolases IPR032466 Metal-dependent hydrolase 128 566 0.0
CDD cd00375 Urease_alpha IPR005848 Urease, alpha subunit 2 565 0.0
NCBIfam TIGR01792 JCVI: urease subunit alpha IPR005848 Urease, alpha subunit 2 566 0.0
PRINTS PR01752 Urea amidohydrolase (urease) protein signature IPR005848 Urease, alpha subunit 400 415 6.5E-34
Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1 IPR011059 Metal-dependent hydrolase, composite domain superfamily 3 479 0.0
PRINTS PR01752 Urea amidohydrolase (urease) protein signature IPR005848 Urease, alpha subunit 294 311 6.5E-34
PANTHER PTHR43440 UREASE - - 2 566 0.0
SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases IPR011059 Metal-dependent hydrolase, composite domain superfamily 417 476 2.01E-6
Pfam PF00449 Urease alpha-subunit, N-terminal domain IPR011612 Urease alpha-subunit, N-terminal domain 1 118 3.0E-56

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.