Pseudomonas aeruginosa PAO1, PA4997 (msbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0015920 lipopolysaccharide transport
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 17644517 Reviewed by curator
Biological Process GO:0009245 lipid A biosynthetic process
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 17644517 Reviewed by curator
Biological Process GO:0006810 transport
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0005347 ATP transmembrane transporter activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 17644517 Reviewed by curator
Molecular Function GO:0016887 ATPase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 17644517 Reviewed by curator
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00664
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02203
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016887 ATPase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00382
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0034040 ATPase-coupled lipid transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02203
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0140359 ABC-type transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00664
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00005
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Fatty acid and phospholipid metabolism Other PAO1 genes in this class
Transport of small molecules Other PAO1 genes in this class
Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02010 ABC transporters 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF90123 ABC transporter transmembrane region IPR036640 ABC transporter type 1, transmembrane domain superfamily 18 338 3.4E-71
NCBIfam TIGR02203 JCVI: lipid A export permease/ATP-binding protein MsbA IPR011917 ABC transporter, lipid A-core flippase, MsbA 15 595 0.0
Gene3D G3DSA:3.40.50.300 - IPR027417 P-loop containing nucleoside triphosphate hydrolase 343 593 2.1E-93
PANTHER PTHR24221 ATP-BINDING CASSETTE SUB-FAMILY B IPR039421 Type 1 protein exporter 85 589 0.0
CDD cd18552 ABC_6TM_MsbA_like - - 30 332 4.01983E-105
Gene3D G3DSA:1.20.1560.10 ABC transporter type 1, transmembrane domain IPR036640 ABC transporter type 1, transmembrane domain superfamily 6 342 1.2E-69
CDD cd03251 ABCC_MsbA - - 356 590 0.0
FunFam G3DSA:3.40.50.300:FF:000140 Lipid A export ATP-binding/permease protein MsbA - - 347 596 8.7E-107
Pfam PF00664 ABC transporter transmembrane region IPR011527 ABC transporter type 1, transmembrane domain 31 306 1.7E-48
Pfam PF00005 ABC transporter IPR003439 ABC transporter-like, ATP-binding domain 373 523 1.6E-32
SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases IPR027417 P-loop containing nucleoside triphosphate hydrolase 346 591 1.33E-94
SMART SM00382 AAA_5 IPR003593 AAA+ ATPase domain 382 575 4.2E-17

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.