Pseudomonas aeruginosa PAO1, PA5038 (aroB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5038
Name
aroB
Replicon chromosome
Genomic location 5674028 - 5675134 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253725.1
GI 15600231
Affymetrix PA5038_aroB_at
Entrez 881253
GenBank AAG08423.1
INSDC AAC36825.1
NCBI Locus Tag PA5038
protein_id(GenBank) gb|AAG08423.1|AE004917_2|gnl|PseudoCAP|PA5038
TIGR NTL03PA05039
UniParc UPI0000125F78
UniProtKB Acc P34002
UniProtKB ID AROB_PSEAE
UniRef100 UniRef100_P34002
UniRef50 UniRef50_P77980
UniRef90 UniRef90_P34002

Product

Feature Type CDS
Coding Frame 1
Product Name
3-dehydroquinate synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.43
Kyte-Doolittle Hydrophobicity Value 0.052
Molecular Weight (kDa) 40.1
Isoelectric Point (pI) 5.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 560 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004643 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5038
Search term: aroB

Human Homologs

References

The complete amino acid sequence of 3-dehydroquinate synthase of Escherichia coli K12.
Millar G, Coggins JR
FEBS Lett 1986 May 5;200(1):11-7
PubMed ID: 3009224