Pseudomonas aeruginosa PAO1, PA5046

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03949
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004470 malic enzyme activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000106
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00390
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF03949 Malic enzyme, NAD binding domain IPR012302 Malic enzyme, NAD-binding 164 354 2.5E-26
Pfam PF00390 Malic enzyme, N-terminal domain IPR012301 Malic enzyme, N-terminal domain 19 148 1.9E-25
PANTHER PTHR43237 NADP-DEPENDENT MALIC ENZYME - - 2 409 0.0
SMART SM01274 malic_2 IPR012301 Malic enzyme, N-terminal domain 17 150 2.0E-76
Gene3D G3DSA:3.40.50.10380 - IPR037062 Malic enzyme, N-terminal domain superfamily 1 159 2.6E-61
Gene3D G3DSA:3.40.50.720 - - - 160 418 3.4E-80
PIRSF PIRSF000106 ME IPR001891 Malic oxidoreductase 44 418 4.2E-72
FunFam G3DSA:3.40.50.720:FF:000095 NADP-dependent malic enzyme - - 160 420 6.7E-118
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 162 412 1.18E-83
FunFam G3DSA:3.40.50.10380:FF:000003 NADP-dependent malic enzyme - - 1 159 4.3E-75
SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily 9 160 5.47E-51
SMART SM00919 Malic_M_2 IPR012302 Malic enzyme, NAD-binding 162 398 0.0
CDD cd05311 NAD_bind_2_malic_enz IPR045213 Malic enzyme, NAD-binding domain, bacterial type 162 397 2.16086E-104

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.