Pseudomonas aeruginosa PAO1, PA5092 (hutI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0050480 imidazolonepropionase activity
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 4290562 Reviewed by curator
Molecular Function GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006548 histidine catabolic process
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 4290562 Reviewed by curator
Biological Process GO:0019556 histidine catabolic process to glutamate and formamide
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01224
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016787 hydrolase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01979
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01224
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01224
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:2.30.40.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc HISDEG-PWY L-histidine degradation I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00340 Histidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR42752 IMIDAZOLONEPROPIONASE IPR005920 Imidazolonepropionase 16 400 0.0
SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases IPR011059 Metal-dependent hydrolase, composite domain superfamily 1 399 1.66E-28
SUPERFAMILY SSF51556 Metallo-dependent hydrolases IPR032466 Metal-dependent hydrolase 60 360 6.56E-86
Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1 IPR011059 Metal-dependent hydrolase, composite domain superfamily 9 392 0.0
Hamap MF_00372 Imidazolonepropionase [hutI]. IPR005920 Imidazolonepropionase 2 399 42.730938
CDD cd01296 Imidazolone-5PH IPR005920 Imidazolonepropionase 26 394 0.0
NCBIfam TIGR01224 JCVI: imidazolonepropionase IPR005920 Imidazolonepropionase 22 394 0.0
Pfam PF01979 Amidohydrolase family IPR006680 Amidohydrolase-related 58 376 7.8E-20
FunFam G3DSA:3.20.20.140:FF:000007 Imidazolonepropionase - - 61 359 2.0E-121
Gene3D G3DSA:3.20.20.140 - - - 61 359 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.