Pseudomonas aeruginosa PAO1, PA5118 (thiI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0052837 thiazole biosynthetic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9209060 Reviewed by curator
Molecular Function GO:0004810 tRNA adenylyltransferase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd01712
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003723 RNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00981
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0052837 thiazole biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR04271
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016783 sulfurtransferase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00342
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0034227 tRNA thio-modification
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00342
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc THISYN-PWY superpathway of thiamin diphosphate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00730 Thiamine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae04122 Sulfur relay system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-6892 thiazole biosynthesis I (E. coli) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.40.250.10 - IPR036873 Rhodanese-like domain superfamily 388 483 7.6E-8
Gene3D G3DSA:3.30.2130.30 - - - 1 176 6.5E-35
Gene3D G3DSA:3.40.50.620 HUPs IPR014729 Rossmann-like alpha/beta/alpha sandwich fold 177 387 2.0E-48
CDD cd11716 THUMP_ThiI - - 2 172 1.75596E-55
Pfam PF02568 Thiamine biosynthesis protein (ThiI) IPR020536 Thil, AANH domain 178 370 2.0E-64
Coils Coil Coil - - 364 384 -
SUPERFAMILY SSF52821 Rhodanese/Cell cycle control phosphatase IPR036873 Rhodanese-like domain superfamily 397 482 5.63E-8
Pfam PF02926 THUMP domain IPR004114 THUMP domain 29 166 1.7E-21
SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like - - 181 374 2.14E-38
Hamap MF_00021 tRNA sulfurtransferase [thiI]. IPR003720 tRNA sulfurtransferase ThiI 1 484 206.371063
NCBIfam TIGR00342 JCVI: tRNA 4-thiouridine(8) synthase ThiI IPR003720 tRNA sulfurtransferase ThiI 4 371 9.2E-106
FunFam G3DSA:3.40.50.620:FF:000029 tRNA sulfurtransferase - - 177 402 1.5E-112
SMART SM00981 THUMP_a_2 IPR004114 THUMP domain 77 167 5.1E-24
CDD cd01712 ThiI IPR020536 Thil, AANH domain 182 355 5.61295E-58
NCBIfam TIGR04271 JCVI: thiazole biosynthesis domain IPR026340 Thiazole biosynthesis domain 386 483 2.4E-35
PANTHER PTHR43209 TRNA SULFURTRANSFERASE - - 1 399 0.0
SUPERFAMILY SSF143437 THUMP domain-like - - 1 175 3.84E-48

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.