Pseudomonas aeruginosa PAO1, PA5215 (gcvT1)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0019464	glycine decarboxylation via glycine cleavage system	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	3023185	Reviewed by curator
Molecular Function	GO:0004047	aminomethyltransferase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_00259	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006546	glycine catabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_00259	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0005515	protein binding	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:3.30.1360.120	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00630	Glyoxylate and dicarboxylate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		One carbon pool by folate		ECO:0000037 not_recorded
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00260	Glycine, serine and threonine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00670	One carbon pool by folate	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01200	Carbon metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Glycine, serine and threonine metabolism		ECO:0000037 not_recorded
PseudoCAP		Nitrogen metabolism		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
FunFam	G3DSA:3.30.70.1400:FF:000001	Aminomethyltransferase	-	-	51	137	9.3E-27
SUPERFAMILY	SSF101790	Aminomethyltransferase beta-barrel domain	IPR029043	Glycine cleavage T-protein/YgfZ, C-terminal	269	357	9.81E-26
PIRSF	PIRSF006487	GCST	-	-	1	358	4.4E-80
FunFam	G3DSA:2.40.30.110:FF:000001	Aminomethyltransferase	-	-	277	360	4.0E-38
NCBIfam	TIGR00528	JCVI: glycine cleavage system aminomethyltransferase GcvT	IPR006223	Glycine cleavage system T protein	4	354	1.0E-124
Gene3D	G3DSA:3.30.70.1400	-	-	-	51	137	1.9E-84
Hamap	MF_00259	Aminomethyltransferase [gcvT].	IPR022903	Glycine cleavage system T protein, bacteria	1	355	43.610336
PANTHER	PTHR43757	AMINOMETHYLTRANSFERASE	IPR028896	Aminomethyltransferase-like	4	356	2.7E-96
Pfam	PF01571	Aminomethyltransferase folate-binding domain	IPR006222	Aminomethyltransferase, folate-binding domain	7	253	7.3E-80
Pfam	PF08669	Glycine cleavage T-protein C-terminal barrel domain	IPR013977	Glycine cleavage T-protein, C-terminal barrel domain	280	353	1.7E-15
Gene3D	G3DSA:2.40.30.110	-	-	-	277	360	1.2E-33
Gene3D	G3DSA:3.30.1360.120	Probable tRNA modification gtpase trme; domain 1	IPR027266	GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1	5	230	1.9E-84
Gene3D	G3DSA:4.10.1250.10	Aminomethyltransferase fragment	-	-	231	274	7.3E-26
FunFam	G3DSA:4.10.1250.10:FF:000001	Aminomethyltransferase	-	-	231	275	5.2E-21
SUPERFAMILY	SSF103025	Folate-binding domain	-	-	4	276	4.55E-87

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.