Pseudomonas aeruginosa PAO1, PA5243 (hemB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004655 porphobilinogen synthase activity
IMP
Inferred from Mutant Phenotype 		ECO:0000015
mutant phenotype evidence		 9529530 Reviewed by curator
Biological Process GO:0006779 porphyrin-containing compound biosynthetic process
IMP
Inferred from Mutant Phenotype 		ECO:0000015
mutant phenotype evidence		 9529530 Reviewed by curator
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11458
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004655 porphobilinogen synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11458
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0033014 tetrapyrrole biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11458
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc P381-PWY adenosylcobalamin biosynthesis II (late cobalt incorporation) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00860 Porphyrin and chlorophyll metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Porphyrin and chlorophyll metabolism ECO:0000037
not_recorded
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-5188 tetrapyrrole biosynthesis I (from glutamate) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature IPR001731 Delta-aminolevulinic acid dehydratase 161 180 1.5E-56
Pfam PF00490 Delta-aminolevulinic acid dehydratase IPR001731 Delta-aminolevulinic acid dehydratase 13 331 0.0
PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature IPR001731 Delta-aminolevulinic acid dehydratase 307 326 1.5E-56
FunFam G3DSA:3.20.20.70:FF:000019 Delta-aminolevulinic acid dehydratase - - 8 335 0.0
PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature IPR001731 Delta-aminolevulinic acid dehydratase 253 269 1.5E-56
PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature IPR001731 Delta-aminolevulinic acid dehydratase 130 144 1.5E-56
PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature IPR001731 Delta-aminolevulinic acid dehydratase 199 218 1.5E-56
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 1 337 0.0
CDD cd04823 ALAD_PBGS_aspartate_rich - - 13 334 0.0
PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature IPR001731 Delta-aminolevulinic acid dehydratase 278 293 1.5E-56
SUPERFAMILY SSF51569 Aldolase - - 8 334 0.0
PANTHER PTHR11458 DELTA-AMINOLEVULINIC ACID DEHYDRATASE IPR001731 Delta-aminolevulinic acid dehydratase 12 333 6.0E-116
PIRSF PIRSF001415 Porphbilin_synth IPR001731 Delta-aminolevulinic acid dehydratase 2 336 0.0
SMART SM01004 ALAD_2 IPR001731 Delta-aminolevulinic acid dehydratase 10 333 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.