Pseudomonas aeruginosa PAO1, PA5259 (hemD)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	2557837	Reviewed by curator
Molecular Function	GO:0004852	uroporphyrinogen-III synthase activity	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:P09126	ECO:0000250 sequence similarity evidence used in manual assertion	2557837	Reviewed by curator
Biological Process	GO:0033014	tetrapyrrole biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:cd06578	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004852	uroporphyrinogen-III synthase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:cd06578	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006780	uroporphyrinogen III biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PTHR38042	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00860	Porphyrin and chlorophyll metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Porphyrin and chlorophyll metabolism		ECO:0000037 not_recorded
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	P381-PWY	adenosylcobalamin biosynthesis II (late cobalt incorporation)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PWY-5188	tetrapyrrole biosynthesis I (from glutamate)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.40.50.10090	-	IPR036108	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily	6	245	3.2E-98
CDD	cd06578	HemD	IPR003754	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase	7	233	3.72337E-54
PANTHER	PTHR38042	UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC	IPR039793	Uroporphyrinogen-III synthase	5	250	1.4E-27
Pfam	PF02602	Uroporphyrinogen-III synthase HemD	IPR003754	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase	17	233	6.0E-32
SUPERFAMILY	SSF69618	HemD-like	IPR036108	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily	3	249	5.75E-55
Gene3D	G3DSA:3.40.50.10090	-	IPR036108	Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily	35	169	3.2E-98

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.