Pseudomonas aeruginosa PAO1, PA5302 (dadX)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0004056	argininosuccinate lyase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Biological Process	GO:0006531	aspartate metabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Biological Process	GO:0046436	D-alanine metabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0008784	alanine racemase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	10977898	Reviewed by curator
Biological Process	GO:0006520	cellular amino acid metabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:SSF50621	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0008784	alanine racemase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PR00992	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006522	alanine metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PR00992	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01502	Vancomycin resistance	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00473	D-Alanine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		D-Alanine metabolism		ECO:0000037 not_recorded
PseudoCAP		Alanine and Aspartate metabolism		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Hamap	MF_01201	Alanine racemase.	IPR000821	Alanine racemase	3	355	56.422371
CDD	cd06827	PLPDE_III_AR_proteobact	-	-	3	354	0.0
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	60	78	2.2E-62
FunFam	G3DSA:2.40.37.10:FF:000002	Alanine racemase	-	-	212	356	3.1E-56
SUPERFAMILY	SSF51419	PLP-binding barrel	IPR029066	PLP-binding barrel	8	233	7.07E-73
Gene3D	G3DSA:2.40.37.10	Lyase, Ornithine Decarboxylase; Chain A, domain 1	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal	212	357	1.3E-54
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	25	41	2.2E-62
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	338	351	2.2E-62
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	286	303	2.2E-62
Pfam	PF01168	Alanine racemase, N-terminal domain	IPR001608	Alanine racemase, N-terminal	8	218	4.9E-70
Gene3D	G3DSA:3.20.20.10	Alanine racemase	IPR029066	PLP-binding barrel	10	211	8.3E-72
PANTHER	PTHR30511	ALANINE RACEMASE	-	-	1	355	3.1E-118
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	191	218	2.2E-62
SUPERFAMILY	SSF50621	Alanine racemase C-terminal domain-like	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal	228	355	1.43E-43
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	154	165	2.2E-62
FunFam	G3DSA:3.20.20.10:FF:000002	Alanine racemase	-	-	10	214	5.5E-68
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	248	263	2.2E-62
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	120	132	2.2E-62
SMART	SM01005	Ala_racemase_C_2	IPR011079	Alanine racemase, C-terminal	232	355	2.6E-64
Pfam	PF00842	Alanine racemase, C-terminal domain	IPR011079	Alanine racemase, C-terminal	232	354	2.8E-40
NCBIfam	TIGR00492	JCVI: alanine racemase	IPR000821	Alanine racemase	3	354	2.6E-107
PRINTS	PR00992	Alanine racemase signature	IPR000821	Alanine racemase	265	280	2.2E-62

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.