Pseudomonas aeruginosa UCBPP-PA14, PA14_62160 (ilvI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0030976 thiamine pyrophosphate binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd02015
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050660 flavin adenine dinucleotide binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02775
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000287 magnesium ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009082 branched-chain amino acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003984 acetolactate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00118
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00650 Butanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00770 Pantothenate and CoA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00660 C5-Branched dibasic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.40.50.1220:FF:000008 Acetolactate synthase - - 190 362 4.2E-58
NCBIfam TIGR00118 JCVI: biosynthetic-type acetolactate synthase large subunit IPR012846 Acetolactate synthase, large subunit, biosynthetic 4 569 0.0
SUPERFAMILY SSF52467 DHS-like NAD/FAD-binding domain IPR029035 DHS-like NAD/FAD-binding domain superfamily 189 360 4.36E-62
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 3 179 9.09E-66
Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain IPR011766 Thiamine pyrophosphate enzyme, TPP-binding 396 545 7.5E-49
FunFam G3DSA:3.40.50.970:FF:000016 Acetolactate synthase - - 366 555 1.7E-73
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 374 567 5.31E-65
Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 5 166 1.0E-58
CDD cd02015 TPP_AHAS IPR039368 Acetolactate synthase large subunit, TPP binding domain 374 556 1.1198E-104
PANTHER PTHR18968 THIAMINE PYROPHOSPHATE ENZYMES IPR045229 Thiamine pyrophosphate enzyme 5 558 0.0
CDD cd07035 TPP_PYR_POX_like - - 8 163 2.44227E-77
Gene3D G3DSA:3.40.50.970 - - - 2 186 1.6E-65
Gene3D G3DSA:3.40.50.1220 - - - 196 363 3.6E-121
Gene3D G3DSA:3.40.50.970 - - - 365 544 3.6E-121
Pfam PF00205 Thiamine pyrophosphate enzyme, central domain IPR012000 Thiamine pyrophosphate enzyme, central domain 196 330 1.0E-43
FunFam G3DSA:3.40.50.970:FF:000007 Acetolactate synthase - - 1 183 1.4E-75

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.