Pseudomonas aeruginosa PAO1, PA2685 (vgrG4)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA2685
Name
vgrG4
Synonym: vgrG1c
Replicon chromosome
Genomic location 3035752 - 3037932 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 10 transposon mutants in orthologs

Cross-References

RefSeq NP_251375.1
GI 15597881
Affymetrix PA2685_at
Entrez 879130
GenBank AAG06073.1
INSDC AAG06073.1
NCBI Locus Tag PA2685
protein_id(GenBank) gb|AAG06073.1|AE004696_7|gnl|PseudoCAP|PA2685
TIGR NTL03PA02685
UniParc UPI00000C57AD
UniProtKB Acc Q9I0F3
UniProtKB ID Q9I0F3_PSEAE
UniRef100 UniRef100_Q9I0F3
UniRef50 UniRef50_Q9I741
UniRef90 UniRef90_Q9I0F3

Product

Feature Type CDS
Coding Frame 1
Product Name
VgrG4
Product Name Confidence: Class 1
Synonyms VgrG1c
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.22
Kyte-Doolittle Hydrophobicity Value -0.511
Molecular Weight (kDa) 81.6
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 147 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000090 (3404 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2685
Search term: vgrG4
Search term: VgrG4

References

Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli.
Wang YD, Zhao S, Hill CW
J. Bacteriol. 1998 Aug;180(16):4102-10
PubMed ID: 9696756
A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.
Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD
Cell Host Microbe 2010 Jan;7(1):25-37
PubMed ID: 20114026
Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins.
Hachani A, Lossi NS, Hamilton A, Jones C, Bleves S, Albesa-Jové D, Filloux A
J. Biol. Chem. 2011 Apr;286(14):12317-27
PubMed ID: 21325275