Pseudomonas aeruginosa UCBPP-PA14, PA14_18970 (pldA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_18970
Name
pldA
Synonym: tle5
Synonym: type VI secretion lipase effector Tle5
Replicon chromosome
Genomic location 1635662 - 1638973 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_789660.1
GI 116051504
Entrez 4381470
INSDC ABJ12740.1
NCBI Locus Tag PA14_18970
UniParc UPI00003960CE
UniProtKB Acc Q02QX6
UniProtKB ID Q02QX6_PSEAB
UniRef100 UniRef100_Q02QX6
UniRef50 UniRef50_Q9HYC2
UniRef90 UniRef90_Q9HYC2

Product

Feature Type CDS
Coding Frame 1
Product Name
phospholipase D
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -4.85
Kyte-Doolittle Hydrophobicity Value -0.312
Molecular Weight (kDa) 122.7
Isoelectric Point (pI) 6.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 18 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002156 (80 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_18970
Search term: pldA
Search term: phospholipase D

Human Homologs

Ensembl 86, assembly GRCh38.p7
phospholipase D2 [Source:HGNC Symbol;Acc:HGNC:9068]
E-value: 3.1e-25
Percent Identity: 32.3

References

Genetic and biochemical analyses of a eukaryotic-like phospholipase D of Pseudomonas aeruginosa suggest horizontal acquisition and a role for persistence in a chronic pulmonary infection model.
Wilderman PJ, Vasil AI, Johnson Z, Vasil ML
Mol. Microbiol. 2001 Jan;39(2):291-303
PubMed ID: 11136451
PubMed ID: 28673999
PubMed ID: 25565226