Pseudomonas aeruginosa UCBPP-PA14, PA14_19010 (tsi3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_19010
Name
tsi3
Replicon chromosome
Genomic location 1641698 - 1642135 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_789662.1
GI 116051503
Entrez 4381469
INSDC ABJ12739.1
NCBI Locus Tag PA14_19010
UniParc UPI00003960CB
UniProtKB Acc Q02QX4
UniProtKB ID Q02QX4_PSEAB
UniRef100 UniRef100_Q02QX4
UniRef50 UniRef50_A6V1U0
UniRef90 UniRef90_Q02QX4

Product

Feature Type CDS
Coding Frame 1
Product Name
Tsi3
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -3.79
Kyte-Doolittle Hydrophobicity Value -0.450
Molecular Weight (kDa) 15.8
Isoelectric Point (pI) 4.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4N80 HYDROLASE/HYDROLASE INHIBITOR 10/16/13 Crystal structure of Tse3-Tsi3 complex PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 97.6
3WA5 HYDROLASE 04/26/13 Crystal Structure of type VI peptidoglycan muramidase effector Tse3 in complex with its cognate immunity protein Tsi3 PSEUDOMONAS AERUGINOSA 1.9 X-RAY DIFFRACTION 98.6
4M5F HYDROLASE INHIBITOR 08/08/13 complex structure of Tse3-Tsi3 PSEUDOMONAS AERUGINOSA 2.5 X-RAY DIFFRACTION 99.2
4LUQ PROTEIN BINDING/TOXIN INHIBITOR 07/25/13 Crystal structure of virulence effector Tse3 in complex with neutralizer Tsi3 PSEUDOMONAS AERUGINOSA 1.77 X-RAY DIFFRACTION 97.6
4N7S HYDROLASE/HYDROLASE INHIBITOR 10/16/13 Crystal structure of Tse3-Tsi3 complex with Zinc ion PSEUDOMONAS AERUGINOSA 2.101 X-RAY DIFFRACTION 99.2
4N88 HYDROLASE/HYDROLASE INHIBITOR 10/17/13 Crystal structure of Tse3-Tsi3 complex with calcium ion PSEUDOMONAS AERUGINOSA 2.8 X-RAY DIFFRACTION 99.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 2 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002157 (303 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_19010
Search term: tsi3
Search term: Tsi3

References

PubMed ID: 28673999
PubMed ID: 24724564