Pseudomonas aeruginosa PAO1, PA1521

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1521
Name
Synonym: gda1
Replicon chromosome
Genomic location 1653106 - 1654410 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250212.1
GI 15596718
Affymetrix PA1521_at
Entrez 883114
GenBank AAG04910.1
INSDC AAG04910.1
NCBI Locus Tag PA1521
protein_id(GenBank) gb|AAG04910.1|AE004580_10|gnl|PseudoCAP|PA1521
TIGR NTL03PA01522
UniParc UPI00000C53BF
UniProtKB Acc Q9I3J2
UniProtKB ID Q9I3J2_PSEAE
UniRef100 UniRef100_Q9I3J2
UniRef50 UniRef50_D7HY01
UniRef90 UniRef90_A0A072ZID5

Product

Feature Type CDS
Coding Frame 1
Product Name
probable guanine deaminase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -14.46
Kyte-Doolittle Hydrophobicity Value -0.198
Molecular Weight (kDa) 48.3
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 441 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003836 (527 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1521

Human Homologs

Ensembl 110, assembly GRCh38.p14
guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212]
E-value: 2.1e-54
Percent Identity: 34.2
Ensembl 110, assembly GRCh38.p14
guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212]
E-value: 2.1e-54
Percent Identity: 34.2
Ensembl 110, assembly GRCh38.p14
guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212]
E-value: 2.1e-54
Percent Identity: 34.2

References

Purine degradation in Pseudomonas aeruginosa and Pseudomonas testosteroni.
Bongaerts GP, Sin IL, Peters AL, Vogels GD
Biochim Biophys Acta 1977 Aug 25;499(1):111-8
PubMed ID: 407941
Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.
Yuan G, Bin JC, McKay DJ, Snyder FF
J Biol Chem 1999 Mar 19;274(12):8175-80
PubMed ID: 10075721