Pseudomonas aeruginosa PAO1, PA1375 (pdxB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0008615 pyridoxine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2681152 Reviewed by curator
Molecular Function GO:0051287 NAD binding
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2681152 Reviewed by curator
Biological Process GO:0042823 pyridoxal phosphate biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2681152 Reviewed by curator
Molecular Function GO:0033711 4-phosphoerythronate dehydrogenase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2681152 Reviewed by curator
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00389
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0008615 pyridoxine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01825
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02826
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046983 protein dimerization activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF11890
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0033711 4-phosphoerythronate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01825
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01825
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Butanoate metabolism ECO:0000037
not_recorded
PseudoCAP Vitamin B6 metabolism ECO:0000037
not_recorded
KEGG pae00750 Vitamin B6 metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
PseudoCyc PYRIDOXSYN-PWY pyridoxal 5'-phosphate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Ascorbate and aldarate metabolism ECO:0000037
not_recorded
PseudoCAP Phenylalanine metabolism ECO:0000037
not_recorded
PseudoCAP Fructose and mannose metabolism ECO:0000037
not_recorded
PseudoCAP Galactose metabolism ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Lysine biosynthesis ECO:0000037
not_recorded
PseudoCAP Nucleotide sugars metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF11890 Domain of unknown function (DUF3410) IPR024531 Erythronate-4-phosphate dehydrogenase, dimerisation domain 289 376 2.5E-22
CDD cd12158 ErythrP_dh IPR020921 Erythronate-4-phosphate dehydrogenase 2 350 0.0
Gene3D G3DSA:3.40.50.720 - - - 1 277 2.2E-118
Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain 107 256 7.6E-35
Hamap MF_01825 Erythronate-4-phosphate dehydrogenase [pdxB]. IPR020921 Erythronate-4-phosphate dehydrogenase 1 363 44.927265
FunFam G3DSA:3.40.50.720:FF:000093 Erythronate-4-phosphate dehydrogenase - - 92 257 2.5E-75
Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 33 277 4.5E-15
Gene3D G3DSA:3.30.1370.170 - IPR038251 PdxB, dimerisation domain superfamily 293 380 6.7E-29
Gene3D G3DSA:3.40.50.720 - - - 92 257 2.2E-118
SUPERFAMILY SSF52283 Formate/glycerate dehydrogenase catalytic domain-like - - 5 103 1.36E-15
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 91 258 5.56E-37
PANTHER PTHR42938 FORMATE DEHYDROGENASE 1 - - 33 274 1.2E-36

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.