Pseudomonas aeruginosa PAO1, PA2624 (idh)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0004318	enoyl-[acyl-carrier-protein] reductase (NADH) activity	IDA Inferred from Direct Assay	ECO:0000002 direct assay evidence
Biological Process	GO:0006091	generation of precursor metabolites and energy	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PTHR36999	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006099	tricarboxylic acid cycle	ISM Inferred from Sequence Model Term mapped from: InterPro:PTHR36999	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
MetaCyc		NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
PseudoCyc	TCA-GLYOX-BYPASS	superpathway of glyoxylate bypass and TCA	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		methylaspartate cycle	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pae00020	Citrate cycle (TCA cycle)	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		partial TCA cycle (obligate autotrophs)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
PseudoCyc	ANARESP1-PWY	anaerobic respiration	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	FERMENTATION-PWY	mixed acid fermentation	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01200	Carbon metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		L-glutamine biosynthesis III	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pae01120	Microbial metabolism in diverse environments	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01210	2-Oxocarboxylic acid metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		ethylene biosynthesis V (engineered)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
MetaCyc		TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pae00480	Glutathione metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	GLYCOLYSIS-TCA-GLYOX-BYPASS	superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
MetaCyc		TCA cycle VII (acetate-producers)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
PseudoCyc	TCA	TCA cycle I (prokaryotic)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PIRSF	PIRSF009407	IDH_monmr	IPR004436	Isocitrate dehydrogenase NADP-dependent, monomeric	1	741	0.0
PANTHER	PTHR36999	ISOCITRATE DEHYDROGENASE [NADP]	IPR004436	Isocitrate dehydrogenase NADP-dependent, monomeric	4	740	0.0
SUPERFAMILY	SSF53659	Isocitrate/Isopropylmalate dehydrogenase-like	-	-	5	740	0.0
NCBIfam	TIGR00178	JCVI: NADP-dependent isocitrate dehydrogenase	IPR004436	Isocitrate dehydrogenase NADP-dependent, monomeric	4	740	0.0
Pfam	PF03971	Monomeric isocitrate dehydrogenase	IPR004436	Isocitrate dehydrogenase NADP-dependent, monomeric	6	738	0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.