Pseudomonas aeruginosa PAO1, PA3569 (mmsB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006552 leucine catabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0006550 isoleucine catabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0044248 cellular catabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0015976 carbon utilization
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03446
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01692
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051287 NAD binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF14833
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00280 Valine, leucine and isoleucine degradation 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Valine, leucine and isoleucine degradation ECO:0000037
not_recorded
PseudoCyc VALDEG-PWY L-valine degradation I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 2 163 2.69E-45
FunFam G3DSA:1.10.1040.10:FF:000006 3-hydroxyisobutyrate dehydrogenase - - 165 298 6.3E-47
Gene3D G3DSA:3.40.50.720 - - - 1 164 4.9E-57
NCBIfam TIGR01692 JCVI: 3-hydroxyisobutyrate dehydrogenase IPR011548 3-hydroxyisobutyrate dehydrogenase 6 295 0.0
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 163 296 3.97E-39
PANTHER PTHR22981 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED - - 2 295 9.0E-111
Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase IPR029154 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain 165 293 8.0E-37
PIRSF PIRSF000103 HIBADH IPR015815 3-hydroxyisobutyrate dehydrogenase-related 1 297 5.2E-79
Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 3 162 1.3E-50
Gene3D G3DSA:1.10.1040.10 - IPR013328 6-phosphogluconate dehydrogenase, domain 2 165 298 1.6E-45

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.