Pseudomonas aeruginosa PAO1, PA3770 (guaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006163 purine nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0009117 nucleotide metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0018659 4-hydroxybenzoate 3-monooxygenase activity
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006164 purine nucleotide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01964
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003938 IMP dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01964
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Purine metabolism ECO:0000037
not_recorded
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-7221 guanosine ribonucleotides de novo biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SMART SM00116 cbs_1 IPR000644 CBS domain 96 143 7.1E-11
SMART SM01240 IMPDH_2 - - 7 475 0.0
SMART SM00116 cbs_1 IPR000644 CBS domain 157 205 6.7E-4
SUPERFAMILY SSF51412 Inosine monophosphate dehydrogenase (IMPDH) - - 2 479 3.53E-127
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 2 488 0.0
SUPERFAMILY SSF54631 CBS-domain pair IPR046342 CBS domain superfamily 94 202 7.07E-26
PIRSF PIRSF000130 IMPDH IPR005990 Inosine-5'-monophosphate dehydrogenase 1 489 0.0
NCBIfam TIGR01302 JCVI: IMP dehydrogenase IPR005990 Inosine-5'-monophosphate dehydrogenase 8 456 0.0
Pfam PF00478 IMP dehydrogenase / GMP reductase domain IPR001093 IMP dehydrogenase/GMP reductase 8 475 0.0
Pfam PF00571 CBS domain IPR000644 CBS domain 148 200 1.4E-5
CDD cd00381 IMPDH IPR001093 IMP dehydrogenase/GMP reductase 8 464 0.0
PANTHER PTHR11911 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED IPR005990 Inosine-5'-monophosphate dehydrogenase 5 483 0.0
Pfam PF00571 CBS domain IPR000644 CBS domain 95 139 3.6E-10
CDD cd04601 CBS_pair_IMPDH - - 94 202 5.56047E-47
FunFam G3DSA:3.20.20.70:FF:000003 GMP reductase - - 1 488 0.0
Hamap MF_01964 Inosine-5'-monophosphate dehydrogenase [guaB]. IPR005990 Inosine-5'-monophosphate dehydrogenase 8 488 83.89801

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.