Pseudomonas aeruginosa PAO1, PA4694 (ilvC)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0009082	branched-chain amino acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	16322583	Reviewed by curator
Molecular Function	GO:0004455	ketol-acid reductoisomerase activity	ISS Inferred from Sequence or Structural Similarity	ECO:0000250 sequence similarity evidence used in manual assertion	16322583	Reviewed by curator
Molecular Function	GO:0050661	NADP binding	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000116	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0009082	branched-chain amino acid biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000116	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004455	ketol-acid reductoisomerase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF000116	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0016491	oxidoreductase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:TIGR00465	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCyc	BRANCHED-CHAIN-AA-SYN-PWY	superpathway of branched amino acid biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	ILEUSYN-PWY	L-isoleucine biosynthesis I (from threonine)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00770	Pantothenate and CoA biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Pantothenate and CoA biosynthesis		ECO:0000037 not_recorded
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00290	Valine, leucine and isoleucine biosynthesis	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Valine, leucine and isoleucine biosynthesis		ECO:0000037 not_recorded
KEGG	pae01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01210	2-Oxocarboxylic acid metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
FunFam	G3DSA:3.40.50.720:FF:000023	Ketol-acid reductoisomerase (NADP(+))	-	-	1	181	6.2E-87
Gene3D	G3DSA:6.10.240.10	-	-	-	182	338	7.6E-70
PANTHER	PTHR21371	KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL	IPR013023	Ketol-acid reductoisomerase	15	330	5.2E-101
Pfam	PF01450	Acetohydroxy acid isomeroreductase, catalytic domain	IPR000506	Ketol-acid reductoisomerase, C-terminal	183	326	1.1E-61
PIRSF	PIRSF000116	IlvC_gammaproteo	IPR014359	Ketol-acid reductoisomerase, prokaryotic	201	332	1.2E-14
Pfam	PF07991	Acetohydroxy acid isomeroreductase, NADPH-binding domain	IPR013116	Ketol-acid reductoisomerase, N-terminal	14	177	3.6E-75
Hamap	MF_00435	Ketol-acid reductoisomerase (NADP(+)) [ilvC].	IPR013023	Ketol-acid reductoisomerase	1	328	44.862247
NCBIfam	TIGR00465	JCVI: ketol-acid reductoisomerase	IPR013023	Ketol-acid reductoisomerase	14	326	7.7E-130
Gene3D	G3DSA:3.40.50.720	-	-	-	1	181	3.6E-81
PIRSF	PIRSF000116	IlvC_gammaproteo	IPR014359	Ketol-acid reductoisomerase, prokaryotic	2	203	7.4E-45
SUPERFAMILY	SSF48179	6-phosphogluconate dehydrogenase C-terminal domain-like	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily	183	332	1.55E-69
SUPERFAMILY	SSF51735	NAD(P)-binding Rossmann-fold domains	IPR036291	NAD(P)-binding domain superfamily	1	182	6.95E-75

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.