Pseudomonas aeruginosa PAO1, PA4839 (speA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0033388	putrescine biosynthetic process from arginine	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	12634339	Reviewed by curator
Molecular Function	GO:0008792	arginine decarboxylase activity	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	12634339	Reviewed by curator
Molecular Function	GO:0008792	arginine decarboxylase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01417	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0006527	arginine catabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01417	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0008295	spermidine biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:MF_01417	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF02784	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCyc	ARGDEG-II-PWY	arginine degradation II	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00330	Arginine and proline metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Arginine and proline metabolism		ECO:0000037 not_recorded
PseudoCAP		Glutamate metabolism		ECO:0000037 not_recorded
PseudoCyc	POLYAMSYN-PWY	superpathway of polyamine biosynthesis I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	PWY0-823	L-arginine degradation III (arginine decarboxylase/agmatinase pathway)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	ARGDEG-PWY	superpathway of L-arginine, putrescine, and 4-aminobutyrate degradation	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	PWY-40	putrescine biosynthesis I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	ARGDEG-III-PWY	L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway)	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PRINTS	PR01179	Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature	IPR000183	Ornithine/DAP/Arg decarboxylase	107	125	2.4E-16
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	203	225	5.1E-69
FunFam	G3DSA:1.20.58.930:FF:000005	Biosynthetic arginine decarboxylase	-	-	369	461	8.7E-63
Coils	Coil	Coil	-	-	440	460	-
CDD	cd06830	PLPDE_III_ADC	IPR002985	Arginine decarboxylase	65	567	0.0
SUPERFAMILY	SSF51419	PLP-binding barrel	IPR029066	PLP-binding barrel	75	352	1.23E-67
PRINTS	PR01179	Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature	IPR000183	Ornithine/DAP/Arg decarboxylase	130	142	2.4E-16
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	468	489	5.1E-69
PANTHER	PTHR43295	ARGININE DECARBOXYLASE	IPR002985	Arginine decarboxylase	12	636	0.0
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	99	113	5.1E-69
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	330	347	5.1E-69
PIRSF	PIRSF001336	ARGDC	IPR002985	Arginine decarboxylase	1	636	0.0
SUPERFAMILY	SSF50621	Alanine racemase C-terminal domain-like	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal	459	567	1.81E-6
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	546	567	5.1E-69
Gene3D	G3DSA:1.10.287.3440	-	-	-	585	636	1.8E-13
Hamap	MF_01417	Biosynthetic arginine decarboxylase [speA].	IPR002985	Arginine decarboxylase	12	636	41.846478
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	75	90	5.1E-69
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	493	518	5.1E-69
Pfam	PF17810	Arginine decarboxylase helical bundle domain	IPR040634	Arginine decarboxylase, helical bundle domain	376	458	2.5E-20
Pfam	PF02784	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	IPR022644	Orn/DAP/Arg decarboxylase 2, N-terminal	100	350	1.6E-43
Gene3D	G3DSA:1.20.58.930	-	-	-	369	461	0.0
FunFam	G3DSA:3.20.20.10:FF:000001	Biosynthetic arginine decarboxylase	-	-	76	352	8.6E-126
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	179	200	5.1E-69
Pfam	PF17944	Arginine decarboxylase C-terminal helical extension	IPR041128	Arginine decarboxylase, C-terminal helical	586	635	6.8E-13
PRINTS	PR01180	Arginine decarboxylase signature	IPR002985	Arginine decarboxylase	153	168	5.1E-69
Gene3D	G3DSA:2.40.37.10	Lyase, Ornithine Decarboxylase; Chain A, domain 1	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal	23	572	0.0
PRINTS	PR01179	Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature	IPR000183	Ornithine/DAP/Arg decarboxylase	246	259	2.4E-16
PRINTS	PR01179	Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature	IPR000183	Ornithine/DAP/Arg decarboxylase	340	359	2.4E-16
Gene3D	G3DSA:3.20.20.10	Alanine racemase	IPR029066	PLP-binding barrel	76	352	0.0
NCBIfam	TIGR01273	JCVI: arginine decarboxylase	IPR002985	Arginine decarboxylase	14	636	0.0
PRINTS	PR01179	Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature	IPR000183	Ornithine/DAP/Arg decarboxylase	546	559	2.4E-16

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.