Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_33820
|
Name |
pvdQ
|
Replicon | chromosome |
Genomic location | 3004988 - 3007276 (+ strand) |
Transposon Mutants | 2 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 3 transposon mutants in orthologs |
RefSeq | YP_790857.1 |
GI | 116050326 |
Entrez | 4380447 |
INSDC | ABJ11562.1 |
NCBI Locus Tag | PA14_33820 |
UniParc | UPI000045D2DE |
UniProtKB Acc | Q02MH9 |
UniProtKB ID | Q02MH9_PSEAB |
UniRef100 | UniRef100_Q02MH9 |
UniRef50 | UniRef50_Q9I194 |
UniRef90 | UniRef90_Q9I194 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
penicillin acylase-related protein
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 0.50 |
Kyte-Doolittle Hydrophobicity Value | -0.348 |
Molecular Weight (kDa) | 84.1 |
Isoelectric Point (pI) | 7.10 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
2WYB | HYDROLASE | 11/16/09 | The quorum quenching N-acyl homoserine lactone acylase PvdQ with a covalently bound dodecanoic acid | PSEUDOMONAS AERUGINOSA | 2.1 | X-RAY DIFFRACTION | 100.0 |
4WKV | HYDROLASE/HYDROLASE Inhibitor | 10/03/14 | n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ | Pseudomonas aeruginosa | 2.1434 | X-RAY DIFFRACTION | 100.0 |
4M1J | HYDROLASE | 08/02/13 | Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue | Pseudomonas aeruginosa | 1.8 | X-RAY DIFFRACTION | 100.0 |
4BTH | HYDROLASE | 06/18/13 | The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains | PSEUDOMONAS AERUGINOSA | 1.9 | X-RAY DIFFRACTION | 99.8 |
3L91 | HYDROLASE | 01/04/10 | Structure of Pseudomonas aerugionsa PvdQ bound to octanoate | Pseudomonas aeruginosa | 1.66 | X-RAY DIFFRACTION | 100.0 |
2WYE | HYDROLASE | 11/16/09 | The quorum quenching N-acyl homoserine lactone acylase PvdQ is an Ntn- Hydrolase with an unusual substrate-binding pocket | PSEUDOMONAS AERUGINOSA | 1.8 | X-RAY DIFFRACTION | 100.0 |
4WKT | HYDROLASE/HYDROLASE Inhibitor | 10/03/14 | n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ | Pseudomonas aeruginosa | 1.782 | X-RAY DIFFRACTION | 100.0 |
5UBK | HYDROLASE | 12/20/16 | Inactive S1A/N269D-cpPvdQ mutant in complex with the pyoverdine precursor PVDIq reveals a specific binding pocket for the D-Tyr of this substrate | Pseudomonas aeruginosa | 2.55 | X-RAY DIFFRACTION | 99.6 |
4WKS | HYDROLASE/HYDROLASE INHIBITOR | 10/03/14 | n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ | Pseudomonas aeruginosa | 1.629 | X-RAY DIFFRACTION | 100.0 |
3SRC | HYDROLASE/HYDROLASE INHIBITOR | 07/07/11 | Structure of Pseudomonas aeruginosa PvdQ bound to NS2028 | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 100.0 |
4K2G | HYDROLASE/HYDROLASE INHIBITOR | 04/09/13 | Structure of Pseudomonas aeruginosa PvdQ bound to BRD-A33442372 | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 100.0 |
3L94 | HYDROLASE | 01/04/10 | Structure of PvdQ covalently acylated with myristate | Pseudomonas aeruginosa | 1.95 | X-RAY DIFFRACTION | 100.0 |
4WKU | HYDROLASE/HYDROLASE Inhibitor | 10/03/14 | n-Alkylboronic Acid Inhibitors Reveal Determinants of Ligand Specificity in the Quorum-Quenching and Siderophore Biosynthetic Enzyme PvdQ | Pseudomonas aeruginosa | 2 | X-RAY DIFFRACTION | 100.0 |
3SRB | HYDROLASE/HYDROLASE INHIBITOR | 07/07/11 | Structure of Pseudomonas aeruginosa PvdQ bound to SMER28 | Pseudomonas aeruginosa | 1.8 | X-RAY DIFFRACTION | 100.0 |
5UBL | HYDROLASE | 12/20/16 | A circularly permuted version of PvdQ (cpPvdQ) | Pseudomonas aeruginosa | 1.8 | X-RAY DIFFRACTION | 100.0 |
4K2F | HYDROLASE/HYDROLASE INHIBITOR | 04/09/13 | Structure of Pseudomonas aeruginosa PvdQ bound to BRD-A08522488 | Pseudomonas aeruginosa | 1.99 | X-RAY DIFFRACTION | 100.0 |
3SRA | HYDROLASE | 07/07/11 | Structure of Pseudomonas aerugionsa PvdQ covalently acylated with myristic acid from PVDIq | Pseudomonas aeruginosa PAO1 | 2.3 | X-RAY DIFFRACTION | 100.0 |
2WYC | HYDROLASE | 11/16/09 | The quorum quenching N-acyl homoserine lactone acylase PvdQ in complex with 3-oxo-lauric acid | PSEUDOMONAS AERUGINOSA | 1.9 | X-RAY DIFFRACTION | 100.0 |
2WYD | HYDROLASE | 11/16/09 | The quorum quenching N-acyl homoserine lactone acylase PvdQ in complex with dodecanoic acid | PSEUDOMONAS AERUGINOSA | 1.901 | X-RAY DIFFRACTION | 100.0 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
Lauric acid | DB03017 | DrugBank | 5.1.4 | Q9I194 | Acyl-homoserine lactone acylase PvdQ | 99.9 | 762 | 0.0e+00 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 181 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003142 (466 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_33820
Search term: pvdQ
Search term: penicillin acylase-related protein
|