Pseudomonas aeruginosa M18, PAM18_1222 (lasB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0051542 elastin biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3724
 ECO:0000249
sequence similarity evidence used in automatic assertion		 1902216
Biological Process GO:0060309 elastin catabolic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA3724
 ECO:0000249
sequence similarity evidence used in automatic assertion		 1902216
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Translation, post-translational modification, degradation Other M18 genes in this class
Secreted Factors (toxins, enzymes, alginate) Other M18 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG paf02024 Quorum sensing 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG paf01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.10.450.40 - - - 118 197 4.2E-22
Gene3D G3DSA:3.10.170.10 - - - 198 349 1.8E-56
Pfam PF03413 Peptidase propeptide and YPEB domain IPR025711 PepSY domain 123 192 8.8E-9
Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain IPR001570 Peptidase M4, C-terminal 348 492 1.0E-36
Gene3D G3DSA:1.10.390.10 Neutral Protease Domain 2 IPR027268 Peptidase M4/M1, CTD superfamily 350 497 3.5E-49
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 357 368 5.8E-26
Pfam PF01447 Thermolysin metallopeptidase, catalytic domain IPR013856 Peptidase M4 domain 208 345 3.4E-33
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 302 322 5.8E-26
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 419 435 5.8E-26
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 336 352 5.8E-26
FunFam G3DSA:3.10.170.10:FF:000002 Elastase - - 198 349 9.9E-98
SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain - - 199 494 1.41E-88
Gene3D G3DSA:3.10.450.490 - - - 30 115 1.1E-11
Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif IPR011096 FTP domain 56 90 3.0E-6
CDD cd09597 M4_TLP - - 234 492 8.53745E-101
PANTHER PTHR33794 BACILLOLYSIN - - 34 492 7.3E-104

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.