Pseudomonas aeruginosa M18, PAM18_4071 (ruvA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0009378 four-way junction helicase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01330
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006310 DNA recombination
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01330
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01330
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00278
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0009379 Holliday junction helicase complex
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF07499
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006281 DNA repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01330
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003678 DNA helicase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00031
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

DNA replication, recombination, modification and repair Other M18 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG paf03440 Homologous recombination 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Hamap MF_00031 Holliday junction branch migration complex subunit RuvA [ruvA]. IPR000085 Holliday junction branch migration complex subunit RuvA 1 201 32.171883
Pfam PF14520 Helix-hairpin-helix domain - - 72 130 4.4E-18
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 73 92 0.72
NCBIfam TIGR00084 JCVI: Holliday junction branch migration protein RuvA IPR000085 Holliday junction branch migration complex subunit RuvA 1 199 3.2E-61
Pfam PF01330 RuvA N terminal domain IPR013849 DNA helicase, Holliday junction RuvA type, domain I, bacterial 1 62 2.4E-24
Pfam PF07499 RuvA, C-terminal domain IPR011114 Holliday junction DNA helicase RuvA, C-terminal 157 200 1.4E-15
SUPERFAMILY SSF50249 Nucleic acid-binding proteins IPR012340 Nucleic acid-binding, OB-fold 1 63 6.85E-20
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 108 127 0.017
SUPERFAMILY SSF46929 DNA helicase RuvA subunit, C-terminal domain IPR036267 RuvA, C-terminal domain superfamily 156 200 1.2E-10
Gene3D G3DSA:1.10.8.10 - - - 155 201 1.3E-18
Gene3D G3DSA:1.10.150.20 - - - 67 140 3.5E-29
SUPERFAMILY SSF47781 RuvA domain 2-like IPR010994 RuvA domain 2-like 66 137 2.54E-22
Coils Coil Coil - - 118 138 -
Gene3D G3DSA:2.40.50.140 - IPR012340 Nucleic acid-binding, OB-fold 1 66 2.5E-28
CDD cd14332 UBA_RuvA_C IPR011114 Holliday junction DNA helicase RuvA, C-terminal 156 198 1.10073E-11

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.