Pseudomonas aeruginosa DK2, PADK2_01770

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004160 dihydroxy-acid dehydratase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00012
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016836 hydro-lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00920
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009082 branched-chain amino acid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00012
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other DK2 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other DK2 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pdk00290 Valine, leucine and isoleucine biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk00770 Pantothenate and CoA biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pdk01210 2-Oxocarboxylic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.50.30.80:FF:000001 Dihydroxy-acid dehydratase - - 419 570 1.9E-66
Gene3D G3DSA:3.50.30.80 - IPR042096 Dihydroxy-acid dehydratase, C-terminal 419 570 4.5E-57
SUPERFAMILY SSF143975 IlvD/EDD N-terminal domain-like IPR037237 IlvD/EDD, N-terminal domain 3 418 0.0
Pfam PF00920 Dehydratase family IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase 34 603 0.0
PANTHER PTHR43661 D-XYLONATE DEHYDRATASE - - 2 607 0.0
Hamap MF_00012 Dihydroxy-acid dehydratase [ilvD]. IPR004404 Dihydroxy-acid dehydratase 4 606 44.983814
NCBIfam TIGR00110 JCVI: dihydroxy-acid dehydratase IPR004404 Dihydroxy-acid dehydratase 18 606 0.0
SUPERFAMILY SSF52016 LeuD/IlvD-like - - 419 606 1.33E-59

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.