Pseudomonas stutzeri A1501, PST_1729 (topA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0003916 | DNA topoisomerase activity |
Inferred from Sequence Model
Term mapped from: InterPro:SM00436
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Cellular Component | GO:0005694 | chromosome |
Inferred from Sequence Model
Term mapped from: InterPro:PF01396
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003677 | DNA binding |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01051
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0003917 | DNA topoisomerase type I (single strand cut, ATP-independent) activity |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01051
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006265 | DNA topological change |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01051
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
|
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| SUPERFAMILY | SSF57783 | Zinc beta-ribbon | - | - | 701 | 744 | 2.21E-8 |
| SUPERFAMILY | SSF56712 | Prokaryotic type I DNA topoisomerase | IPR023405 | DNA topoisomerase, type IA, core domain | 3 | 611 | 0.0 |
| Pfam | PF01396 | Topoisomerase DNA binding C4 zinc finger | IPR013498 | DNA topoisomerase, type IA, zn finger | 711 | 746 | 2.7E-10 |
| Hamap | MF_00952 | DNA topoisomerase 1 [topA]. | IPR028612 | DNA topoisomerase I, type IA | 3 | 733 | 58.906563 |
| CDD | cd03363 | TOPRIM_TopoIA_TopoI | IPR034149 | DNA topoisomerase 1, TOPRIM domain | 3 | 158 | 1.57047E-59 |
| SUPERFAMILY | SSF57783 | Zinc beta-ribbon | - | - | 745 | 807 | 6.29E-17 |
| Pfam | PF01131 | DNA topoisomerase | IPR013497 | DNA topoisomerase, type IA, central | 161 | 568 | 0.0 |
| Pfam | PF01396 | Topoisomerase DNA binding C4 zinc finger | IPR013498 | DNA topoisomerase, type IA, zn finger | 601 | 624 | 8.6E-4 |
| Pfam | PF08272 | Topoisomerase I zinc-ribbon-like | IPR013263 | DNA topoisomerase I, zinc ribbon-like, bacterial-type | 825 | 864 | 2.2E-21 |
| Pfam | PF08272 | Topoisomerase I zinc-ribbon-like | IPR013263 | DNA topoisomerase I, zinc ribbon-like, bacterial-type | 758 | 794 | 3.7E-12 |
| PRINTS | PR00417 | Prokaryotic DNA topoisomerase I signature | IPR013497 | DNA topoisomerase, type IA, central | 494 | 508 | 1.8E-37 |
| SMART | SM00437 | topIaneu2 | IPR003602 | DNA topoisomerase, type IA, DNA-binding domain | 276 | 531 | 4.6E-122 |
| PRINTS | PR00417 | Prokaryotic DNA topoisomerase I signature | IPR013497 | DNA topoisomerase, type IA, central | 394 | 410 | 1.8E-37 |
| FunFam | G3DSA:1.10.290.10:FF:000002 | DNA topoisomerase 1 | - | - | 284 | 408 | 2.0E-63 |
| PRINTS | PR00417 | Prokaryotic DNA topoisomerase I signature | IPR013497 | DNA topoisomerase, type IA, central | 318 | 327 | 1.8E-37 |
| NCBIfam | TIGR01051 | JCVI: type I DNA topoisomerase | IPR005733 | DNA topoisomerase I, bacterial-type | 5 | 635 | 0.0 |
| PRINTS | PR00417 | Prokaryotic DNA topoisomerase I signature | IPR013497 | DNA topoisomerase, type IA, central | 110 | 123 | 1.8E-37 |
| SUPERFAMILY | SSF57783 | Zinc beta-ribbon | - | - | 810 | 866 | 3.23E-23 |
| CDD | cd00186 | TOP1Ac | IPR013497 | DNA topoisomerase, type IA, central | 164 | 579 | 0.0 |
| Gene3D | G3DSA:2.70.20.10 | Topoisomerase I, domain 3 | IPR013825 | DNA topoisomerase, type IA, central region, subdomain 2 | 217 | 477 | 0.0 |
| Gene3D | G3DSA:3.30.65.10 | Bacterial Topoisomerase I, domain 1 | - | - | 586 | 643 | 7.8E-12 |
| Gene3D | G3DSA:3.30.65.10 | Bacterial Topoisomerase I, domain 1 | - | - | 699 | 745 | 2.1E-11 |
| Gene3D | G3DSA:2.20.25.10 | - | - | - | 810 | 866 | 2.0E-28 |
| Pfam | PF01751 | Toprim domain | IPR006171 | TOPRIM domain | 5 | 146 | 3.4E-33 |
| PRINTS | PR00417 | Prokaryotic DNA topoisomerase I signature | IPR013497 | DNA topoisomerase, type IA, central | 195 | 213 | 1.8E-37 |
| Gene3D | G3DSA:1.10.290.10 | Topoisomerase I, domain 4 | IPR013826 | DNA topoisomerase, type IA, central region, subdomain 3 | 284 | 408 | 0.0 |
| SMART | SM00436 | topIban2 | IPR003601 | DNA topoisomerase, type IA, domain 2 | 137 | 225 | 4.6E-50 |
| PANTHER | PTHR42785 | DNA TOPOISOMERASE, TYPE IA, CORE | IPR000380 | DNA topoisomerase, type IA | 2 | 664 | 0.0 |
| SMART | SM00493 | toprim5 | IPR006171 | TOPRIM domain | 3 | 136 | 2.4E-32 |
| FunFam | G3DSA:3.40.50.140:FF:000001 | DNA topoisomerase 1 | - | - | 1 | 167 | 4.0E-76 |
| MobiDBLite | mobidb-lite | consensus disorder prediction | - | - | 36 | 60 | - |
| Gene3D | G3DSA:3.30.65.10 | Bacterial Topoisomerase I, domain 1 | - | - | 746 | 808 | 1.9E-18 |
| Gene3D | G3DSA:1.10.460.10 | Topoisomerase I, domain 2 | IPR013824 | DNA topoisomerase, type IA, central region, subdomain 1 | 168 | 575 | 0.0 |
| FunFam | G3DSA:3.30.65.10:FF:000002 | DNA topoisomerase 1 | - | - | 586 | 645 | 1.8E-25 |
| Gene3D | G3DSA:3.40.50.140 | - | - | - | 1 | 167 | 4.1E-66 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.