Pseudomonas sp. UW4, PputUW4_00387 (putA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0010133 proline catabolic process to glutamate
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006355 regulation of transcription, DNA-templated
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006561 proline biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01238
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.309.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003700 DNA-binding transcription factor activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004657 proline dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF53720
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000197
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG ppuu00250 Alanine, aspartate and glutamate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG ppuu01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc L-<i>N<sup>&delta;</sup></i>-acetylornithine biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc ethylene biosynthesis II (microbes) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc (5<i>R</i>)-carbapenem carboxylate biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG ppuu00330 Arginine and proline metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG ppuu01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG ppuu01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR42862 DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED - - 234 1313 0.0
SUPERFAMILY SSF53720 ALDH-like IPR016161 Aldehyde/histidinol dehydrogenase 654 1107 0.0
FunFam G3DSA:3.20.20.220:FF:000004 Bifunctional protein PutA - - 215 607 0.0
Gene3D G3DSA:3.40.309.10 Aldehyde Dehydrogenase; Chain A, domain 2 IPR016163 Aldehyde dehydrogenase, C-terminal 882 1076 0.0
Pfam PF18327 Proline utilization A proline dehydrogenase N-terminal domain IPR041349 Proline utilization A proline dehydrogenase N-terminal domain 86 133 1.0E-17
FunFam G3DSA:1.20.5.460:FF:000001 Bifunctional protein PutA - - 159 184 4.7E-16
Pfam PF14850 DNA-binding domain of Proline dehydrogenase IPR024082 Proline dehydrogenase PutA, domain II 145 256 1.4E-44
PIRSF PIRSF000197 Bifunct_PutA IPR025703 Bifunctional protein PutA 71 1316 0.0
Gene3D G3DSA:1.10.1220.10 - IPR013321 Arc-type ribbon-helix-helix 11 52 4.2E-22
CDD cd07125 ALDH_PutA-P5CDH - - 624 1107 0.0
Pfam PF00171 Aldehyde dehydrogenase family IPR015590 Aldehyde dehydrogenase domain 655 1101 2.5E-116
CDD cd22233 RHH_CopAso-like - - 4 45 5.08509E-10
FunFam G3DSA:3.40.605.10:FF:000017 Bifunctional protein PutA - - 649 887 9.2E-116
Gene3D G3DSA:1.20.5.460 Single helix bin - - 159 184 1.6E-15
SUPERFAMILY SSF51730 FAD-linked oxidoreductase IPR029041 FAD-linked oxidoreductase-like 259 615 3.22E-123
Gene3D G3DSA:1.20.5.550 Single Helix bin IPR024090 Proline dehydrogenase PutA, domain I 84 135 8.0E-22
Gene3D G3DSA:3.20.20.220 - - - 218 607 0.0
Pfam PF01619 Proline dehydrogenase IPR002872 Proline dehydrogenase domain 266 566 1.2E-92
Gene3D G3DSA:3.40.605.10 Aldehyde Dehydrogenase; Chain A, domain 1 IPR016162 Aldehyde dehydrogenase, N-terminal 647 1107 0.0
FunFam G3DSA:1.20.5.550:FF:000001 Bifunctional protein PutA - - 84 135 3.3E-26
SUPERFAMILY SSF47598 Ribbon-helix-helix IPR010985 Ribbon-helix-helix 3 45 2.37E-10
FunFam G3DSA:3.40.309.10:FF:000005 1-pyrroline-5-carboxylate dehydrogenase 1 - - 882 1076 7.3E-60
SUPERFAMILY SSF81935 N-terminal domain of bifunctional PutA protein IPR024089 Proline dehydrogenase PutA, domain I/II 85 258 8.11E-65
NCBIfam TIGR01238 JCVI: L-glutamate gamma-semialdehyde dehydrogenase IPR005933 Bifunctional protein PutA, C-terminal domain 607 1107 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.