Pseudomonas aeruginosa PA7, PSPA7_0525 (mexA)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_0525
Name	mexA
Replicon	chromosome
Genomic location	538220 - 539548 (+ strand)

Cross-References

RefSeq	YP_001345920.1
GI	152989389
Entrez	5355727
INSDC	ABR86572.1
NCBI Locus Tag	PSPA7_0525
UniParc	UPI00015770E1
UniProtKB Acc	A6UYN5
UniProtKB ID	A6UYN5_PSEA7
UniRef100	UniRef100_A6UYN5
UniRef50	UniRef50_P52477
UniRef90	UniRef90_P52477

Product

Feature Type	CDS
Coding Frame	1
Product Name	RND multidrug efflux membrane fusion protein MexA
Synonyms
Evidence for Translation
Charge (pH 7)	5.18
Kyte-Doolittle Hydrophobicity Value	-0.213
Molecular Weight (kDa)	47356.5
Isoelectric Point (pI)	9.41

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name	Definition	Accession	Model Type (?)	SNP	Cutoff	Bit Score	Percent Identity	CARD Version
MexA	MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex. [PMID:15117957]	ARO:3000377	protein homolog model		Strict	715.7	99.74	3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6TA5	ANTIMICROBIAL PROTEIN	10/29/19	OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs	Pseudomonas aeruginosa	3.2	ELECTRON MICROSCOPY	99.7
1T5E	TRANSPORT PROTEIN	05/04/04	The structure of MexA	Pseudomonas aeruginosa	3	X-RAY DIFFRACTION	99.7
6TA6	ANTIMICROBIAL PROTEIN	10/29/19	MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs	Pseudomonas aeruginosa	3.2	ELECTRON MICROSCOPY	99.7

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 396 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000416 (526 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_0525 Search term: mexA Search term: RND multidrug efflux membrane fusion protein MexA

Human Homologs

References