Pseudomonas aeruginosa PA7, PSPA7_1346 (guaB)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_1346
Name	guaB
Replicon	chromosome
Genomic location	1357905 - 1359374 (+ strand)

Cross-References

RefSeq	YP_001346730.1
GI	152983713
EC Number	1.1.1.205
Entrez	5355919
INSDC	ABR80896.1
NCBI Locus Tag	PSPA7_1346
UniParc	UPI00000C5B02
UniProtKB Acc	A6V0Z5
UniProtKB ID	A6V0Z5_PSEA7
UniRef100	UniRef100_W0YYK6
UniRef50	UniRef50_P21879
UniRef90	UniRef90_S6AG33

Product

Feature Type	CDS
Coding Frame	1
Product Name	inosine 5'-monophosphate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7)	-1.36
Kyte-Doolittle Hydrophobicity Value	0.027
Molecular Weight (kDa)	51.7
Isoelectric Point (pI)	6.65

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6GK9	OXIDOREDUCTASE	05/18/18	Inhibited structure of IMPDH from Pseudomonas aeruginosa	Pseudomonas aeruginosa PAO1	2.54	X-RAY DIFFRACTION	100.0
7PJI	OXIDOREDUCTASE	08/24/21	Crystal structure of Pseudomonas aeruginosa guaB (IMP dehydrogenase) bound to ATP and GDP at 1.65A resolution	Pseudomonas aeruginosa	1.65	X-RAY DIFFRACTION	100.0
3ZFH	OXIDOREDUCTASE	12/11/12	Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase	PSEUDOMONAS AERUGINOSA PAO1	2.25	X-RAY DIFFRACTION	100.0
6GJV	OXIDOREDUCTASE	05/17/18	apo-structure of IMPDH from Pseudomonas aeruginosa	Pseudomonas aeruginosa PAO1	2.11	X-RAY DIFFRACTION	100.0
4DQW	OXIDOREDUCTASE	02/16/12	Crystal Structure Analysis of PA3770	Pseudomonas aeruginosa	2.51	X-RAY DIFFRACTION	100.0
4AVF	OXIDOREDUCTASE	05/25/12	Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase	PSEUDOMONAS AERUGINOSA	2.23	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 631 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001893 (537 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_1346 Search term: guaB Search term: inosine 5'-monophosphate dehydrogenase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000346219 inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052] E-value: 5.9e-90 Percent Identity: 42.1
Ensembl 110, assembly GRCh38.p14	ENSP00000345096 inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052] E-value: 5.9e-90 Percent Identity: 42.1
Ensembl 110, assembly GRCh38.p14	ENSP00000265385 inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052] E-value: 5.9e-90 Percent Identity: 42.1

References